Nwankwo Emeka A, Bakari Abubakar A, Ene Aloy C
Saudi J Kidney Dis Transpl. 2008 Nov;19(6):904-10.
The number of kidney allograft recipients has been increasing worldwide and along with that is a proportional rise in the number of individuals who develop post-transplantation diabetes mellitus (PTDM). It is therefore necessary that physicians who render care to transplant recipients, be conversant with the current issues that relate to this relatively common complication. We searched the Medline using the keywords diabetes, transplantation, kidney and PTDM, and retrieved all relevant articles that were published in the last 15 years up to 2008. Post-transplantation diabetes mellitus is a common complication following renal trans-plantation affecting approximately 10 to 20% of such patients. In the majority of the studies we reviewed, PTDM was similar to diabetes in non-transplant patients and the risk factors included older age at transplantation, family history of diabetes, obesity, elevated body mass index, non-white ethnicity and the use of steroids and several immunosuppressive agents. Curtailment of the heavy disease burden associated with PTDM should lay emphasis on pro-active preventive measures that are aimed at modifying the known risk factors and the individualized use of immunosuppressive agents determined by the pre-transplant risk profile of the patient.
全球范围内，肾移植受者的数量一直在增加，与此同时，移植后糖尿病（PTDM）患者的数量也相应上升。因此，为移植受者提供治疗的医生有必要熟悉与这种相对常见并发症相关的当前问题。我们使用关键词“糖尿病”“移植”“肾脏”和“PTDM”在Medline数据库中进行检索，获取了截至2008年过去15年发表的所有相关文章。移植后糖尿病是肾移植后常见的并发症，约10%至20%的此类患者会受其影响。在我们回顾的大多数研究中，PTDM与非移植患者的糖尿病相似，危险因素包括移植时年龄较大、糖尿病家族史、肥胖、体重指数升高、非白种人种族以及使用类固醇和几种免疫抑制剂。减轻与PTDM相关的沉重疾病负担应强调采取积极的预防措施，旨在改变已知的危险因素，并根据患者移植前的风险状况个体化使用免疫抑制剂。
