香叶基香叶基丙酮对顺铂耳毒性的保护作用。
Protective effect of geranylgeranylacetone on cisplatin ototoxicity.
作者信息
Yin Hai Ying, Ma Xiu Fang, Liu Fang, Xia Ming, Xu An Ting
机构信息
Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Wen Hua Xi Road 107, Jinan, China.
出版信息
Chemotherapy. 2009;55(1):1-5. doi: 10.1159/000166382. Epub 2008 Oct 31.
BACKGROUND
Geranylgeranylacetone (GGA) has the ability to induce heat shock proteins and to protect cells from apoptotic insults. This study aims to investigate whether GGA has a protective effect on cisplatin (CDDP) ototoxicity.
METHODS
The auditory threshold was assessed using the auditory brainstem response test. Hsp70 and C-reactive protein expressions were investigated by Western blot analysis. The amount of hair cells was counted under scanning electron microscopy.
RESULTS
The auditory threshold and the percentage of missing outer hair cells in the CDDP group were significantly higher than in the GGA + CDDP group. C-reactive protein expression was less in the GGA + CDDP group compared with the CDDP group. Hsp70 expression showed an adverse result.
CONCLUSION
It was suggested that GGA had a protective effect on CDDP ototoxicity.
背景
香叶基香叶基丙酮（GGA）具有诱导热休克蛋白的能力，并能保护细胞免受凋亡损伤。本研究旨在探讨GGA对顺铂（CDDP）耳毒性是否具有保护作用。
方法
采用听觉脑干反应测试评估听觉阈值。通过蛋白质印迹分析研究热休克蛋白70（Hsp70）和C反应蛋白的表达。在扫描电子显微镜下计数毛细胞数量。
结果
CDDP组的听觉阈值和外毛细胞缺失百分比显著高于GGA + CDDP组。与CDDP组相比，GGA + CDDP组的C反应蛋白表达较少。Hsp70表达结果相反。
结论
提示GGA对CDDP耳毒性具有保护作用。
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