Christensen Erik I, Verroust Pierre J
Department of Cell Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark.
Kidney Int. 2008 Nov;74(10):1233-6. doi: 10.1038/ki.2008.421.
The pathogenesis of renal interstitial fibrosis leading eventually to renal failure is highly debatable. Whereas the so-called tubular hypothesis, involving an increased tubular uptake of potentially toxic substances that induce a variety of cytokines, growth factors, and profibrogenic factors, is based to a large extent on cell-culture studies, the glomerular hypothesis is based mainly on careful morphological observations. Unraveling the pathways appears to be extremely complex, but in vivo studies appear to offer the most reliable results.
最终导致肾衰竭的肾间质纤维化的发病机制极具争议性。所谓的肾小管假说，涉及肾小管对潜在毒性物质的摄取增加，这些物质会诱导多种细胞因子、生长因子和促纤维化因子，该假说在很大程度上基于细胞培养研究；而肾小球假说主要基于细致的形态学观察。阐明这些途径似乎极其复杂，但体内研究似乎能提供最可靠的结果。
