Farris Alton B, Alpers Charles E
Department of Pathology and Laboratory Medicine, Emory University , Atlanta, Georgia, USA.
Department of Pathology, University of Washington , Seattle, Washington, USA.
Kidney Int Suppl (2011). 2014 Nov;4(1):9-15. doi: 10.1038/kisup.2014.3.
Interstitial fibrosis is a hallmark structural correlate of progressive and chronic kidney disease. There remain many uncertainties about how to best measure interstitial fibrosis both in research settings and in evaluations of renal biopsies performed for management of individual patients. Areas of uncertainty include determination of the composition of the matrix in a fibrotic parenchyma, the definition of how the interstitium is involved by fibrosing injuries, the choice of histologic stains for evaluation of renal fibrosis, and the reproducibility and robustness of measures currently employed by pathologists, both with and without the assistance of computerized imaging and assessments. In this review, we address some of these issues while citing the key studies that illustrate these difficulties. We point to future approaches that may allow a more accurate and meaningful assessment of renal interstitial fibrosis.
间质纤维化是进行性和慢性肾病的标志性结构特征。在研究环境以及为个体患者管理而进行的肾活检评估中，关于如何最佳测量间质纤维化仍存在许多不确定性。不确定的领域包括纤维化实质中基质成分的确定、纤维化损伤累及间质的定义、评估肾纤维化的组织学染色选择，以及病理学家目前采用的测量方法（无论有无计算机成像和评估辅助）的可重复性和稳健性。在本综述中，我们在引用说明这些困难的关键研究的同时，讨论其中一些问题。我们指出未来可能允许对肾间质纤维化进行更准确和有意义评估的方法。
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