Vaidyanathan T K, Vaidyanathan Jayalakshmi
Department of Restorative Dentistry, NJ Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA.
J Biomed Mater Res B Appl Biomater. 2009 Feb;88(2):558-78. doi: 10.1002/jbm.b.31253.
Dentin bonding issues involving adhesive resins have attracted considerable research interest in recent years. An important advance due to the ongoing research is the concept of hybridization of the tissue with primer/adhesive systems. Hybridization involves permeation of primer monomer into the tissue substrate. Although the mechanism of adhesive permeation and interaction with tissue may be complex, significant advances have been made. In systems where etching precedes priming and bonding steps, the Hoy's solubility parameter compatibility of the primer formulation with that of demineralized dentin matrix may determine adhesive permeability. Monomer permeation brings the primer atoms in closer contact with the substrate atoms, leading to adhesive interactions through van der Waals, hydrogen bonding, and electrostatic interactions. In self-etch primer systems, stronger electrostatic interaction between primer monomers and hydroxyapatite has been used to explain the adhesion process. These interactions have been computer-modeled and analyzed. Such interactions and subsequent polymerization of the monomer promote improved bond strength and efficient margin sealing. Incomplete permeation of monomer into the full depth of demineralized region may, however, leave exposed collagen fibrils and cause nanoleakage of water into these regions through a 20-100 nm sized marginal gap, leading to subsequent hydrolytic degradation of these collagen fibrils and the hybrid layer. Microleakage is also a problem in some single step formulations. In this review, we analyze these current theoretical and mechanism-related issues of interest in adhesive resin bonding to dentin, and outline the continuing problems that need to be overcome in the future.
近年来，涉及粘结树脂的牙本质粘结问题引起了相当大的研究兴趣。正在进行的研究取得的一项重要进展是组织与底漆/粘结系统杂交的概念。杂交涉及底漆单体渗透到组织基质中。尽管粘结剂渗透及其与组织相互作用的机制可能很复杂，但已经取得了重大进展。在酸蚀先于底漆和粘结步骤的系统中，底漆配方与脱矿牙本质基质的霍伊溶解度参数兼容性可能决定粘结剂的渗透性。单体渗透使底漆原子与基质原子更紧密接触，通过范德华力、氢键和静电相互作用导致粘结相互作用。在自酸蚀底漆系统中，底漆单体与羟基磷灰石之间更强的静电相互作用已被用于解释粘结过程。这些相互作用已通过计算机建模和分析。这种相互作用以及随后的单体聚合促进了粘结强度的提高和边缘密封的有效性。然而，单体未完全渗透到脱矿区域的整个深度可能会使胶原纤维暴露，并通过20-100纳米大小的边缘间隙导致水渗入这些区域，从而导致这些胶原纤维和混合层随后发生水解降解。微渗漏在一些单步配方中也是一个问题。在这篇综述中，我们分析了目前粘结树脂与牙本质粘结中这些与理论和机制相关的问题，并概述了未来需要克服的持续问题。
