Singh Urmila, Gupta H P, Singh R K, Shukla Manju, Singh Ranjana, Mehrotra Seema Sinha Nee, Prasad Shweta
Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow.
J Indian Med Assoc. 2008 Aug;106(8):503-5.
To find out changes in homocysteine levels that occur during normal pregnancy and pregnancy with pre-eclamptic toxaemia and also to find out correlation between homocysteine concentration and preeclamptic toxaemia a study was carried out among 90 women of which 30 were control which included normotensive non-pregnant women and the study group I comprised 30 pregnant normotensive women and the study group II comprised 30 pregnant women with pre-eclamptic toxaemia. Serum homocysteine was measured in all subjects using fluorescence polarisation immuno-assay. Control group had highest mean homocysteine levels while the study group I had least mean homocysteine levels (p < 0.001). Levels were significantly higher in subjects with BP > 146/100 mm Hg as compared to subjects with BP >140/90 and <146/100 mm Hg (p=0.017). There was significant difference between study group I and II at same gestational age. Hyperhomocysteinaemia was observed in pre-eclamptic females, also it was found that homocysteine levels were directly correlated with severity of pre-eclampsia.
为了找出正常妊娠期间以及妊娠合并先兆子痫时同型半胱氨酸水平的变化，并找出同型半胱氨酸浓度与先兆子痫之间的相关性，对90名女性进行了一项研究，其中30名作为对照组，包括血压正常的未怀孕女性，研究组I包括30名血压正常的孕妇，研究组II包括30名患有先兆子痫的孕妇。使用荧光偏振免疫分析法对所有受试者的血清同型半胱氨酸进行测量。对照组的平均同型半胱氨酸水平最高，而研究组I的平均同型半胱氨酸水平最低（p<0.001）。与血压>140/90且<146/100 mmHg的受试者相比，血压>146/100 mmHg的受试者的同型半胱氨酸水平显著更高（p=0.017）。在相同孕周时，研究组I和II之间存在显著差异。先兆子痫女性中观察到高同型半胱氨酸血症，还发现同型半胱氨酸水平与先兆子痫的严重程度直接相关。
