Yamamoto Shingo, Mitsui Youzou, Ueda Yasuo, Suzuki Toru, Higuchi Yoshihide, Qiu Jun, Maruyama Takuo, Kondou Nobuyuki, Nojima Michio, Takesue Yoshio, Shima Hiroki
Department of Urology, Hyogo College of Medicine.
Hinyokika Kiyo. 2008 Sep;54(9):587-91.
A single-dose ofantimicrobial prophylaxis (AMP) was administered parenterally for prevention of perioperative infection in a total of 206 urologic surgeries including 114 endoscopic-instrumental, 92 clean, and 20 clean-contaminated procedures between January and December, 2007, and surgical site infections (SSI), urinary tract infections (UTI), and remote infections (RI) were prospectively surveyed. The definition of a single-dose of AMP allowed the administration of a second dose of an antimicrobial during a surgical procedure that exceeded 3 hours but not parenteral or oral administration at the end of the procedure, in the recovery room, or at a later time over a period of more than 24 hours. UTI was observed in 3 cases (2.7%) after endoscopic-instrumental procedures and in 1 case (5%) after clean-contaminated procedures while no case was associated with UTI in clean procedures. SSI was seen in 1 case each after clean procedures (1.1%) and after clean-contaminated procedures (5%), and RI was seen in 2 cases (2.2%) after clean procedures. A single-dose regimen of AMP was effective for prevention ofperioperative infections including SSI, UTI, and RI in endoscopic-instrumental, clean, and clean-contaminated surgical procedures in urology.
2007年1月至12月期间，对总共206例泌尿外科手术采用单剂量抗菌药物预防（AMP）进行围手术期感染预防，其中包括114例内镜器械手术、92例清洁手术和20例清洁-污染手术，并对手术部位感染（SSI）、尿路感染（UTI）和远处感染（RI）进行前瞻性调查。单剂量AMP的定义允许在手术时间超过3小时的手术过程中给予第二剂抗菌药物，但在手术结束时、恢复室或术后超过24小时的后续时间内不得进行胃肠外或口服给药。内镜器械手术后观察到3例UTI（2.7%），清洁-污染手术后观察到1例UTI（5%），而清洁手术中未出现与UTI相关的病例。清洁手术后有1例发生SSI（1.1%），清洁-污染手术后有1例发生SSI（5%），清洁手术后有2例发生RI（2.2%）。单剂量AMP方案在泌尿外科内镜器械手术、清洁手术和清洁-污染手术中对预防包括SSI、UTI和RI在内的围手术期感染有效。
