Koizumi Koji, Mizusawa Hiroya, Oguchi Tomohiko, Domen Takahisa, Kato Haruaki
Department of Urology, Nagano National Hospital.
Hinyokika Kiyo. 2008 Sep;54(9):603-6.
A 33-year-old woman was referred to our hospital for further examination of a right adrenal mass 4.5 cm in diameter. Hormonal findings were normal. Computed tomography, magnetic resonance image and angiograpy demonstrated non-functioning adrenal tumor. Right nephrectomy was performed, because the tumor adhered firmly to the upper pole of the right kidney. The pathological diagnosis was nephroblastoma (nephroblastic type, complex subtype). Postoperative chemotherapy was started for stage III Wilms' tumor. However, peripheral neuropathy such as numbness of the fingers developed. Therefore, chemotherapy was discontinued in the fifth week. The patient is currently alive without recurrence 17 months postoperatively. In adult patients, postoperative chemotherapy for nephroblastoma is often interrupted due to side effects. Further studies on the protocol for adults is necessary.
一名33岁女性因进一步检查直径4.5厘米的右侧肾上腺肿块而被转诊至我院。激素检查结果正常。计算机断层扫描、磁共振成像和血管造影显示为无功能肾上腺肿瘤。由于肿瘤与右肾上极紧密粘连，故行右肾切除术。病理诊断为肾母细胞瘤（肾母细胞型，复杂亚型）。针对III期威尔姆斯瘤开始术后化疗。然而，出现了诸如手指麻木等周围神经病变。因此，化疗在第五周中断。患者术后17个月目前仍存活，无复发。在成年患者中，肾母细胞瘤的术后化疗常因副作用而中断。有必要对成人治疗方案进行进一步研究。
