Mazonakis Michalis, Zacharopoulou Fotini, Varveris Haralambos, Damilakis John
Department of Medical Physics, University Hospital of Iraklion, 71110 Iraklion, Greece.
Med Phys. 2008 Oct;35(10):4396-403. doi: 10.1118/1.2977533.
Peripheral dose (PD) to critical structures outside treatment volume is of clinical importance. The aim of the current study was to estimate PD on a linear accelerator equipped with multileaf collimator (MLC). Dose measurements were carried out using an ionization chamber embedded in a water phantom for 6 and 18 MV photon beams. PD values were acquired for field sizes from 5 x 5 to 20 x 20 cm2 in increments of 5 cm at distances up to 24 cm from the field edge. Dose data were obtained at two collimator orientations where the measurement points are shielded by MLC and jaws. The variation of PD with the source to skin distance (SSD), depth, and lateral displacement of the measurement point was evaluated. To examine the dependence of PD upon the tissue thickness at the entrance point of the beam, scattered dose was measured using thermoluminescent dosemeters placed on three anthropomorphic phantoms simulating 5- and 10-year-old children and an average adult patient. PD from 6 MV photons varied from 0.13% to 6.75% of the central-axis maximum dose depending upon the collimator orientation, extent of irradiated area, and distance from the treatment field. The corresponding dose range from 18 MV x rays was 0.09% to 5.61%. The variation of PD with depth and with lateral displacements up to 80% of the field dimension was very small. The scattered dose from both photon beams increased with the increase of SSD or tissue thickness along beam axis. The presented dosimetric data set allows the estimation of scattered dose outside the primary beam.
治疗体积外关键结构的外周剂量(PD)具有临床重要性。本研究的目的是估计配备多叶准直器(MLC)的直线加速器上的外周剂量。使用嵌入水模体中的电离室对6和18 MV光子束进行剂量测量。在距射野边缘最远24 cm处,以5 cm的增量获取5×5至20×20 cm2射野大小的外周剂量值。在两个准直器方向上获取剂量数据,测量点由多叶准直器和铅门屏蔽。评估了外周剂量随源皮距(SSD)、深度和测量点横向位移的变化。为了研究外周剂量对射束入射点处组织厚度的依赖性,使用置于三个模拟5岁和10岁儿童以及一名成年患者的人体模型上的热释光剂量计测量散射剂量。6 MV光子的外周剂量占中心轴最大剂量的0.13%至6.75%,具体取决于准直器方向、照射区域范围和距治疗野的距离。18 MV X射线的相应剂量范围为0.09%至5.61%。外周剂量随深度以及横向位移(直至射野尺寸的80%)的变化非常小。两种光子束的散射剂量均随源皮距或沿射束轴的组织厚度增加而增加。所呈现的剂量学数据集可用于估计原射线束外的散射剂量。