Garrett Lachlan, Hardcastle Nicholas, Yeo Adam, Lonski Peta, Franich Rick, Kron Tomas
RMIT University, School of Science, Melbourne, Australia.
Peter MacCallum Cancer Centre, Department of Physical Sciences, Melbourne, Australia.
Phys Imaging Radiat Oncol. 2021 Jun 4;19:1-5. doi: 10.1016/j.phro.2021.05.006. eCollection 2021 Jul.
Stereotactic radiotherapy combines image guidance and high precision delivery with small fields to deliver high doses per fraction in short treatment courses. In preparation for extension of these treatment techniques to paediatric patients we characterised and compared doses out-of-field in a paediatric anthropomorphic phantom for small flattened and flattening filter free (FFF) photon beams.
Dose measurements were taken in several organs and structures outside the primary field in an anthropomorphic phantom of a 5 year old child (CIRS) using thermoluminescence dosimetry (LiF:Mg,Cu,P). Out-of-field doses from a medical linear accelerator were assessed for 6 MV flattened and FFF beams of field sizes between 2 × 2 and 10 × 10 cm.
FFF beams resulted in reduced out-of-field doses for all field sizes when compared to flattened beams. Doses for FFF and flattened beams converged for all field sizes at larger distances (>40 cm) from the central axis as leakage becomes the primary source of out-of-field dose. Rotating the collimator to place the MLC bank in the longitudinal axis of the patient was shown to reduce the peripheral doses measured by up to 50% in Varian linear accelerators.
Minimising out-of-field doses by using FFF beams and aligning the couch and collimator to provide tertiary shielding demonstrated advantages of small field, FFF treatments in a paediatric setting.
立体定向放射治疗结合图像引导和小射野的高精度剂量投送,在短疗程中每次分割给予高剂量。为将这些治疗技术扩展至儿科患者做准备,我们在一个儿科人体模型中对小的扁平光子束和无均整器(FFF)光子束的射野外剂量进行了表征和比较。
使用热释光剂量测定法(LiF:Mg,Cu,P),在一个5岁儿童的人体模型(CIRS)的原射野之外的多个器官和结构中进行剂量测量。评估了医用直线加速器产生的6MV扁平光子束和FFF光子束在2×2至10×10cm射野尺寸下的射野外剂量。
与扁平光子束相比,FFF光子束在所有射野尺寸下均导致射野外剂量降低。对于所有射野尺寸,当距中心轴的距离较大(>40cm)时,FFF光子束和扁平光子束的剂量趋于一致,因为泄漏成为射野外剂量的主要来源。在瓦里安直线加速器中,将准直器旋转以使多叶准直器组位于患者的纵轴上,可使测量的周边剂量降低多达50%。
在儿科环境中,使用FFF光子束并调整治疗床和准直器以提供三级屏蔽来最小化射野外剂量,证明了小射野FFF治疗的优势。