Laboratory of Polymer Chemistry, Eindhoven University of Technology, Den Dolech 2, Post Office Box 513, 5600 MB Eindhoven, The Netherlands.
Biomacromolecules. 2008 Dec;9(12):3404-10. doi: 10.1021/bm800898c.
We systematically investigated a series of polymers derived from macrolactones, namely, pentadecalactone, hexadecalactone, and their unsaturated analogues ambrettolide and globalide as potential biomaterials. By enzymatic ring-opening polymerization these monomers can conveniently be polymerized to high molecular weight. The polymers are highly crystalline with melting points around 95 degrees C for the saturated polymers and lower melting points for the unsaturated polymers (46-55 degrees C). All polymers are nontoxic as measured by an MTT assay for metabolic cell activity of a 3T3 mouse fibroblast cell line. Degradation studies showed no hydrolytic or enzymatic degradability of the polymers, which was ascribed to the high crystallinity and hydrophobicity of the materials. The unsaturated polymers were cross-linked in the melt, yielding fully amorphous transparent materials with a gel content of 97%.
我们系统地研究了一系列源自大环内酯的聚合物，即十五内酯、十六内酯及其不饱和类似物金合欢内酯和环球内酯，它们作为潜在的生物材料。通过酶促开环聚合，这些单体可以方便地聚合至高相对分子质量。这些聚合物具有高结晶性，其熔点为饱和聚合物约 95°C，而不饱和聚合物的熔点较低（46-55°C）。所有聚合物的细胞毒性均通过 3T3 小鼠成纤维细胞系的 MTT 测定法进行测量，结果表明它们无代谢活性。降解研究表明，聚合物没有水解或酶解降解性，这归因于材料的高结晶度和疏水性。不饱和聚合物在熔融状态下交联，生成完全无定形透明材料，凝胶含量为 97%。
