氧化应激下哺乳动物的乌头酸水合酶
Aconitate hydratase of mammals under oxidative stress.
作者信息
Matasova L V, Popova T N
机构信息
Voronezh State University, Voronezh, 394006, Russia.
出版信息
Biochemistry (Mosc). 2008 Sep;73(9):957-64. doi: 10.1134/s0006297908090010.
Abstract
Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.
摘要
本文综述了哺乳动物胞质和线粒体乌头酸水合酶同工酶的结构、功能、活性调节及表达的数据。描述了乌头酸水合酶和结构相似的铁调节蛋白在维持细胞铁稳态中的作用。总结了关于乌头酸水合酶分子修饰及氧化应激下表达变化的信息。探讨了乌头酸水合酶在某些疾病发病机制中的作用。
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