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氧化应激下哺乳动物的乌头酸水合酶

Aconitate hydratase of mammals under oxidative stress.

作者信息

Matasova L V, Popova T N

机构信息

Voronezh State University, Voronezh, 394006, Russia.

出版信息

Biochemistry (Mosc). 2008 Sep;73(9):957-64. doi: 10.1134/s0006297908090010.

DOI:10.1134/s0006297908090010
PMID:18976211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7087844/
Abstract

Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.

摘要

本文综述了哺乳动物胞质和线粒体乌头酸水合酶同工酶的结构、功能、活性调节及表达的数据。描述了乌头酸水合酶和结构相似的铁调节蛋白在维持细胞铁稳态中的作用。总结了关于乌头酸水合酶分子修饰及氧化应激下表达变化的信息。探讨了乌头酸水合酶在某些疾病发病机制中的作用。

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Aconitate hydratase of mammals under oxidative stress.氧化应激下哺乳动物的乌头酸水合酶
Biochemistry (Mosc). 2008 Sep;73(9):957-64. doi: 10.1134/s0006297908090010.
2
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本文引用的文献

1
The role of iron regulatory proteins in mammalian iron homeostasis and disease.铁调节蛋白在哺乳动物铁稳态及疾病中的作用。
Nat Chem Biol. 2006 Aug;2(8):406-14. doi: 10.1038/nchembio807.
2
Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane.人类线粒体DNA类核与线粒体内膜处的蛋白质折叠机制及代谢酶相连。
J Biol Chem. 2006 Sep 1;281(35):25791-802. doi: 10.1074/jbc.M604501200. Epub 2006 Jul 6.
3
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice.阿霉素治疗小鼠中心脏铁代谢的不依赖铁调节蛋白1的改变
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Association of calcineurin with mitochondrial proteins.钙调神经磷酸酶与线粒体蛋白的关联。
Proteins. 2006 Jul 1;64(1):28-33. doi: 10.1002/prot.20996.
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Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells.锰拮抗铁，从而阻断人前列腺癌细胞中线粒体乌头酸酶的表达。
Asian J Androl. 2006 May;8(3):307-15. doi: 10.1111/j.1745-7262.2006.00139.x.
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Temporal responses in the disruption of iron regulation by manganese.锰对铁调节的干扰中的时间响应。
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7
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.人类单核细胞、巨噬细胞和十二指肠中的铁调节蛋白1和2：遗传性血色素沉着症和缺铁状态下的表达与调控
Haematologica. 2006 Mar;91(3):303-10. Epub 2006 Feb 17.
8
Iron regulatory protein 1 as a sensor of reactive oxygen species.铁调节蛋白1作为活性氧的传感器。
Biofactors. 2005;24(1-4):171-81. doi: 10.1002/biof.5520240121.
9
Altered metabolism and mitochondrial genome in prostate cancer.前列腺癌中代谢和线粒体基因组的改变。
J Clin Pathol. 2006 Jan;59(1):10-6. doi: 10.1136/jcp.2005.027664.
10
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.线粒体乌头酸酶是转谷氨酰胺酶2的底物：转谷氨酰胺作用可能是导致亨廷顿病大脑中乌头酸酶高分子量聚集体形成及乌头酸酶活性丧失的一种机制。
Neurochem Res. 2005 Oct;30(10):1245-55. doi: 10.1007/s11064-005-8796-x.