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Single step multiple genotyping by MALDI-TOF mass spectrometry, for evaluation of minor histocompatibility antigens in patients submitted to allogeneic stem cell transplantation from HLA-matched related and unrelated donor.通过基质辅助激光解吸电离飞行时间质谱进行单步多重基因分型，用于评估接受来自HLA匹配的相关和无关供体的异基因干细胞移植患者的次要组织相容性抗原。
Hematol Rep. 2017 Sep 26;9(3):7051. doi: 10.4081/hr.2017.7051.
2
Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation.多中心分析表明，在 HLA 匹配的相关和无关造血干细胞移植后，次要组织相容性抗原对移植物抗宿主病和移植物抗肿瘤效应具有显著的临床影响。
Biol Blood Marrow Transplant. 2013 Aug;19(8):1244-53. doi: 10.1016/j.bbmt.2013.06.001. Epub 2013 Jun 10.
3
Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.预测的次要组织相容性抗原错配程度与非清髓性异基因造血细胞移植的临床结局较差相关。
Biol Blood Marrow Transplant. 2010 Oct;16(10):1370-81. doi: 10.1016/j.bbmt.2010.03.022. Epub 2010 Mar 28.
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The impact of H-Y mismatches on results of HLA-matched unrelated allogeneic hematopoietic stem cell transplantation.H-Y错配对于人类白细胞抗原（HLA）匹配的非亲缘异基因造血干细胞移植结果的影响。
Transplant Proc. 2010 Oct;42(8):3297-300. doi: 10.1016/j.transproceed.2010.07.029.
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Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow Transplantation registry retrospective analysis.来自HLA匹配供者和替代供者的异基因造血干细胞移植的结局：欧洲血液与骨髓移植学会登记处的回顾性分析
Lancet Haematol. 2019 Nov;6(11):e573-e584. doi: 10.1016/S2352-3026(19)30158-9. Epub 2019 Aug 30.
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Domestic and foreign donor candidates result in differential probability of matching minor histocompatibility antigens--relevance of selection for hematopoietic stem cell transplantation.国内外供体候选者导致次要组织相容性抗原匹配概率存在差异——对造血干细胞移植选择的相关性。
Tissue Antigens. 2009 Mar;73(3):236-41. doi: 10.1111/j.1399-0039.2008.01210.x.
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Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens.计算建模和确认白血病相关的次要组织相容性抗原。
Blood Adv. 2018 Aug 28;2(16):2052-2062. doi: 10.1182/bloodadvances.2018022475.
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How to select the best available related or unrelated donor of hematopoietic stem cells?如何选择最佳的造血干细胞相关或无关供体？
Haematologica. 2016 Jun;101(6):680-7. doi: 10.3324/haematol.2015.141119. Epub 2016 May 31.
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Transplantations from HLA-identical siblings versus 10/10 HLA-matched unrelated donors.来自 HLA 全相合同胞的移植与 10/10 HLA 配型相合的无关供者的移植。
Semin Hematol. 2016 Apr;53(2):74-6. doi: 10.1053/j.seminhematol.2016.01.013. Epub 2016 Jan 15.
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Minor histocompatibility antigens as targets of graft-versus-leukemia reactions.次要组织相容性抗原作为移植物抗白血病反应的靶点。
Curr Opin Hematol. 2002 Nov;9(6):497-502. doi: 10.1097/00062752-200211000-00005.

引用本文的文献

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The Applications of Machine Learning in the Management of Patients Undergoing Stem Cell Transplantation: Are We Ready?机器学习在接受干细胞移植患者管理中的应用：我们准备好了吗？
Cancers (Basel). 2025 Jan 25;17(3):395. doi: 10.3390/cancers17030395.
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MALDI-MS: Emerging roles in pathology and laboratory medicine.基质辅助激光解吸电离质谱：在病理学和检验医学中的新作用
Clin Mass Spectrom. 2019 May 18;13:1-4. doi: 10.1016/j.clinms.2019.05.003. eCollection 2019 Aug.

本文引用的文献

1
Reprint of: Acute Graft-versus-Host Disease: Novel Biological Insights.重印：急性移植物抗宿主病：新的生物学见解。
Biol Blood Marrow Transplant. 2016 Mar;22(3 Suppl):S3-8. doi: 10.1016/j.bbmt.2016.01.004.
2
Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation.多中心分析表明，在 HLA 匹配的相关和无关造血干细胞移植后，次要组织相容性抗原对移植物抗宿主病和移植物抗肿瘤效应具有显著的临床影响。
Biol Blood Marrow Transplant. 2013 Aug;19(8):1244-53. doi: 10.1016/j.bbmt.2013.06.001. Epub 2013 Jun 10.
3
High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning.高通量全基因组关联扫描分析 10 个新的次要组织相容性抗原。
Cancer Res. 2010 Nov 15;70(22):9073-83. doi: 10.1158/0008-5472.CAN-10-1832. Epub 2010 Nov 9.
4
Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.预测的次要组织相容性抗原错配程度与非清髓性异基因造血细胞移植的临床结局较差相关。
Biol Blood Marrow Transplant. 2010 Oct;16(10):1370-81. doi: 10.1016/j.bbmt.2010.03.022. Epub 2010 Mar 28.
5
Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens.异基因造血细胞移植后针对次要组织相容性抗原的 T 细胞治疗复发白血病。
Blood. 2010 May 13;115(19):3869-78. doi: 10.1182/blood-2009-10-248997. Epub 2010 Jan 13.
6
Immunomonitoring of graft-versus-host minor histocompatibility antigen correlates with graft-versus-host disease and absence of relapse after graft.移植后移植物抗宿主病和无复发的移植与次要组织相容性抗原免疫监测相关。
Transfusion. 2010 Feb;50(2):418-28. doi: 10.1111/j.1537-2995.2009.02440.x. Epub 2009 Oct 15.
7
Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.鉴定4种新的HLA-DR限制性次要组织相容性抗原作为抗肿瘤免疫中的造血靶点。
Blood. 2009 Oct 22;114(17):3684-92. doi: 10.1182/blood-2009-03-208017. Epub 2009 Aug 25.
8
Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009.异基因和自体移植治疗血液系统疾病、实体瘤和免疫性疾病：2009 年欧洲的现状。
Bone Marrow Transplant. 2010 Feb;45(2):219-34. doi: 10.1038/bmt.2009.141. Epub 2009 Jul 6.
9
Effects of mismatching for minor histocompatibility antigens on clinical outcomes in HLA-matched, unrelated hematopoietic stem cell transplants.次要组织相容性抗原错配在人类白细胞抗原匹配的非亲缘造血干细胞移植中对临床结局的影响。
Biol Blood Marrow Transplant. 2009 Jul;15(7):856-63. doi: 10.1016/j.bbmt.2009.03.018.
10
Non-HLA genetics and predicting outcome in HSCT.非人类白细胞抗原遗传学与造血干细胞移植的预后预测
Int J Immunogenet. 2008 Aug;35(4-5):375-80. doi: 10.1111/j.1744-313X.2008.00790.x.

Single step multiple genotyping by MALDI-TOF mass spectrometry, for evaluation of minor histocompatibility antigens in patients submitted to allogeneic stem cell transplantation from HLA-matched related and unrelated donor.

作者信息

Cattina Federica, Bernardi Simona, Mantovani Vilma, Toffoletti Eleonora, Santoro Alessandra, Pastore Domenico, Martino Bruno, Console Giuseppe, Martinelli Giovanni, Malagola Michele

机构信息

Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili of Brescia.

Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, Bologna.

出版信息

Hematol Rep. 2017 Sep 26;9(3):7051. doi: 10.4081/hr.2017.7051.

DOI:10.4081/hr.2017.7051
PMID:29071050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5641860/
Abstract
摘要