Bigum Lene Hyldgaard, Jensen Jørgen Bjerggaard, Jensen Klaus Møller-Ernst, Thind Peter
Ole Suhrs gade 6, 4. tv., DK-1354 København K.
Ugeskr Laeger. 2008 Oct 20;170(43):3416-9.
Since 1999, Rigshospitalet (RH) and Aarhus University Hospital, Skejby (SKS) have been offering women an orthotopic neobladder following cystectomy. The aim of the present study was to describe the function of the neobladders in women by examining continence and voiding function. Cancer stage, cancer recurrence, complications and mortality are also described.
The data was retrospectively collected from patient files. Between 1999 and 2006, a total of 20 female patients at RH and SKS underwent reconstructive surgery with a neobladder. Continence and voiding function were evaluated from existing tests and examinations performed during follow-up.
The average follow-up was 3.1 years (range: 0.4-7.4). The average age was 57.1 years (40.1-70.6). Fifteen patients (75%) were continent during the daytime, and three of the patients (15%) were incontinent during the night-time. Five patients (25%) were partly incontinent during the day- and night-time, but in two of the patients the incontinence was related to recurrence. Eight patients (40%) used intermittent catheterization as a supplement to the spontaneous voiding. Ten patients (50%) had early complications. Six patients (30%) had late complications. The most common complication was pyelonephritis. Fifteen patients (75%) were alive at the end of follow-up, and twelve patients (60%) were without recurrence.
Neobladders in women after cystectomy function adequately. Patients achieve a high degree of continence and acceptable bladder emptying. However, the best functional results were seen in patients without cancer recurrence.
自1999年以来，里格霍斯皮塔利特医院（RH）和奥胡斯大学医院斯凯比分院（SKS）一直在为女性患者在膀胱切除术后提供原位新膀胱。本研究的目的是通过检查控尿和排尿功能来描述女性新膀胱的功能。同时也描述了癌症分期、癌症复发、并发症和死亡率。
数据是从患者病历中回顾性收集的。1999年至2006年期间，RH和SKS共有20名女性患者接受了新膀胱重建手术。根据随访期间进行的现有检查和测试对控尿和排尿功能进行评估。
平均随访时间为3.1年（范围：0.4 - 7.4年）。平均年龄为57.1岁（40.1 - 70.6岁）。15名患者（75%）白天能自主控尿，3名患者（15%）夜间失禁。5名患者（25%）白天和夜间部分失禁，但其中2名患者的失禁与复发有关。8名患者（40%）使用间歇性导尿作为自主排尿的补充。10名患者（50%）出现早期并发症。6名患者（30%）出现晚期并发症。最常见的并发症是肾盂肾炎。随访结束时15名患者（75%）存活，12名患者（60%）无复发。
膀胱切除术后女性的新膀胱功能良好。患者实现了高度的控尿和可接受的膀胱排空。然而，在无癌症复发的患者中观察到最佳的功能结果。
