Tanida Mamoru, Satomi Jun, Shen Jiao, Nagai Katsuya
Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan.
Physiol Behav. 2009 Feb 16;96(2):282-8. doi: 10.1016/j.physbeh.2008.10.008. Epub 2008 Oct 17.
Previous studies have demonstrated that neuromedin U (NMU) affects cardiovascular functions such as blood pressure (BP) or heart rate (HR) in rats. Here, we examined the effects of the lateral cerebral ventricular (ICV) injection of various doses of NMU on renal sympathetic nerve activity (RSNA) and BP in urethane-anesthetized rats. ICV injection of NMU elevated RSNA, BP and HR in a dose-dependent manner. Moreover, neither ICV pretreatment of thioperamide, an antagonist of histaminergic H3-receptor, or of diphenhydramine, an antagonist of histaminergic H1-receptor, abolished increasing effects of NMU on RSNA, BP and HR In addition, ICV injection of NMU suppressed gastric vagal nerve activity (GVNA) and activated brown adipose tissue sympathetic nerve activity (BAT-SNA) of anesthetized rats, and elevated brown adipose tissue temperature (BAT-T) of conscious rats. Thus, these evidence suggest that NMU affects neural activities of autonomic nerves containing RSNA, GVNA or BAT-SNA, and BP by mediating central mechanism.
先前的研究表明，神经介素U（NMU）会影响大鼠的心血管功能，如血压（BP）或心率（HR）。在此，我们研究了向侧脑室（ICV）注射不同剂量的NMU对氨基甲酸乙酯麻醉大鼠肾交感神经活动（RSNA）和血压的影响。向ICV注射NMU会以剂量依赖的方式提高RSNA、BP和HR。此外，组胺能H3受体拮抗剂硫代哌啶或组胺能H1受体拮抗剂苯海拉明进行ICV预处理，均不能消除NMU对RSNA、BP和HR的增强作用。另外，向ICV注射NMU会抑制麻醉大鼠的胃迷走神经活动（GVNA），并激活其棕色脂肪组织交感神经活动（BAT-SNA），还会提高清醒大鼠的棕色脂肪组织温度（BAT-T）。因此，这些证据表明，NMU通过介导中枢机制影响包含RSNA、GVNA或BAT-SNA的自主神经的神经活动以及血压。
