Ren Xiaojie, Dong Fang, Zhuang Yuerong, Wang Yong, Ma Wuhua
Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China.
Department of Anaesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China.
Exp Ther Med. 2020 Feb;19(2):809-816. doi: 10.3892/etm.2019.8283. Epub 2019 Dec 4.
Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU) plays a pleiotropic role in the pathogenesis of asthma. NMU is a highly structurally conserved neuropeptide that was first purified from porcine spinal cord and named for its contractile effect on the rat uterus. NMU amplifies type 2 innate lymphoid cell (ILC2)-driven allergic lung inflammation. The NMU receptors (NMURs), designated as NMUR1 and NMUR2, belong to the G protein-coupled receptor family. NMUR1 has also been found in immune cells, including ILC2s, mast cells and eosinophils. In view of the important roles of NMU in the pathogenesis of asthma, the present review evaluates the potential mechanisms underlying the impact of NMU on asthma and its association with asthma therapy.
哮喘是一种发病率和死亡率都很高的主要气道炎症性疾病。全球哮喘防治创议组织在2004年发布了一份名为《全球哮喘负担》的报告。然而，哮喘的具体发病机制仍不清楚。越来越多的研究表明，神经介素U（NMU）在哮喘发病机制中发挥多效性作用。NMU是一种结构高度保守的神经肽，最初从猪脊髓中纯化出来，并因其对大鼠子宫的收缩作用而得名。NMU会加剧2型固有淋巴细胞（ILC2）驱动的过敏性肺部炎症。NMU受体（NMURs）分为NMUR1和NMUR2，属于G蛋白偶联受体家族。在包括ILC2、肥大细胞和嗜酸性粒细胞在内的免疫细胞中也发现了NMUR1。鉴于NMU在哮喘发病机制中的重要作用，本综述评估了NMU影响哮喘的潜在机制及其与哮喘治疗的关联。
