Teti Anna, Zallone Alberta
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.
Bone. 2009 Jan;44(1):11-6. doi: 10.1016/j.bone.2008.09.017. Epub 2008 Oct 14.
Osteocytes are cells buried in the bone matrix. They largely contribute to the regulation of bone remodeling in response to mechanical and microenvironmental changes. Much has been recognized in recent years regarding the role of osteocytes in bone homeostasis, nevertheless their ability to directly contribute to mineral equilibrium has been neglected. In the light of the renewed interest in their biology, we revisited the literature and discuss experimental evidence favoring the hypothesis that osteocytes are able to remove and replace the bone matrix according to the systemic needs of the body. We also reviewed reports against this theory, thus providing current views of what is known so far on the ability of osteocytes to mobilize bone mineral. This re-examination of osteocytic osteolysis might stimulate new interest and open new perspectives in osteocyte biology and in the cellular mechanisms that control bone homeostasis.
骨细胞是埋在骨基质中的细胞。它们在很大程度上有助于响应机械和微环境变化而调节骨重塑。近年来，关于骨细胞在骨稳态中的作用已得到广泛认可，然而它们直接促进矿物质平衡的能力却被忽视了。鉴于对其生物学的重新关注，我们回顾了文献，并讨论了支持骨细胞能够根据身体的系统需求去除和替换骨基质这一假说的实验证据。我们还回顾了反对该理论的报告，从而提供了目前关于骨细胞动员骨矿物质能力的已知观点。对骨细胞性骨溶解的这种重新审视可能会激发新的兴趣，并为骨细胞生物学以及控制骨稳态的细胞机制开辟新的视角。
