Nakashima Tomoki
Department of Cell Signaling, Tokyo Medical and Dental University, Japan.
Clin Calcium. 2013 Feb;23(2):218-28.
Bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic bone resorption both of which mainly occur at the bone surface. This restructuring process called "bone remodeling" is important not only for normal bone mass and strength, but also for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone component cells such as osteoclasts, osteoblasts and osteocytes. An imbalance of this process is often linked to various bone diseases. During bone remodeling, resorption by osteoclasts precedes bone formation by osteoblasts. Based on the osteocyte location within the bone matrix and the cellular morphology, it is proposed that osteocytes potentially contribute to the controls of bone remodeling. Thus, the elucidation of the regulatory mechanisms involved in bone remodeling is critical for a deeper understanding of the skeletal system in health and disease.
骨通过成骨细胞的骨形成和破骨细胞的骨吸收之间的平衡作用不断更新，这两个过程主要发生在骨表面。这个被称为“骨重塑”的重构过程不仅对正常的骨量和强度很重要，而且对矿物质稳态也很重要。骨重塑受到破骨细胞、成骨细胞和骨细胞等骨组成细胞之间通讯的严格调控。这个过程的失衡通常与各种骨疾病有关。在骨重塑过程中，破骨细胞的吸收先于成骨细胞的骨形成。基于骨细胞在骨基质中的位置和细胞形态，有人提出骨细胞可能有助于控制骨重塑。因此，阐明骨重塑所涉及的调控机制对于更深入地理解健康和疾病状态下的骨骼系统至关重要。
