Al Riyami Nafila, Zimmerman Amanda C, Rosenberg Frances M, Holmes Daniel T
University of British Columbia Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada.
Clin Biochem. 2009 Jan;42(1-2):129-31. doi: 10.1016/j.clinbiochem.2008.09.119. Epub 2008 Oct 21.
To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose.
Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis.
O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin.
O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.
