Landhuis Carl Erik, Poulton Richie, Welch David, Hancox Robert John
Department of Preventive and Social Medicine, Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Pediatrics. 2008 Nov;122(5):955-60. doi: 10.1542/peds.2007-3521.
Associations between short sleep duration and increased BMI have been found in children and adults. However, it is not known whether short sleep time during childhood has long-term consequences. We assessed the association between sleep time in childhood and adult BMI in a birth cohort.
Study members were a general-population birth cohort of 1037 participants (502 female) who were born in Dunedin, New Zealand, between April 1972 and March 1973. Parental reports of bedtimes and rising times collected at ages 5, 7, 9, and 11 years were used to estimate childhood sleep time. Linear regression analysis was used to analyze the association between childhood sleep time and BMI measured at 32 years of age.
Shorter childhood sleep times were significantly associated with higher adult BMI values. This association remained after adjustment for adult sleep time and the potential confounding effects of early childhood BMI, childhood socioeconomic status, parental BMIs, child and adult television viewing, adult physical activity, and adult smoking. In logistic regression analyses, more sleep time during childhood was associated with lower odds of obesity at 32 years of age. This association was significant after adjustment for multiple potential confounding factors.
These findings suggest that sleep restriction in childhood increases the long-term risk for obesity. Ensuring that children get adequate sleep may be a useful strategy for stemming the current obesity epidemic.
在儿童和成人中均发现了短睡眠时间与体重指数（BMI）升高之间的关联。然而，儿童时期的短睡眠时间是否会产生长期后果尚不清楚。我们在一个出生队列中评估了儿童时期睡眠时间与成人BMI之间的关联。
研究对象是1972年4月至1973年3月在新西兰达尼丁出生的1037名参与者（502名女性）的普通人群出生队列。利用在5、7、9和11岁时收集的父母报告的就寝时间和起床时间来估计儿童时期的睡眠时间。采用线性回归分析来分析儿童时期睡眠时间与32岁时测量的BMI之间的关联。
儿童时期睡眠时间较短与成人较高的BMI值显著相关。在对成人睡眠时间以及儿童早期BMI、儿童社会经济地位、父母BMI、儿童和成人看电视时间、成人身体活动及成人吸烟等潜在混杂效应进行校正后，这种关联依然存在。在逻辑回归分析中，儿童时期睡眠时间较长与32岁时肥胖几率较低相关。在对多个潜在混杂因素进行校正后，这种关联具有显著性。
这些发现表明，儿童时期睡眠受限会增加肥胖的长期风险。确保儿童获得充足睡眠可能是遏制当前肥胖流行的一项有效策略。
