Derks Ivonne P M, Kocevska Desana, Jaddoe Vincent W V, Franco Oscar H, Wake Melissa, Tiemeier Henning, Jansen Pauline W
1 Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center , Rotterdam, The Netherlands .
2 The Generation R Study Group, Erasmus MC-University Medical Center , Rotterdam, The Netherlands .
Child Obes. 2017 Oct;13(5):400-408. doi: 10.1089/chi.2016.0341. Epub 2017 Jun 12.
A short sleep duration is associated with a higher obesity risk from midchildhood onward. However, whether sleep duration in early childhood is associated with body composition and cardiometabolic health remains unclear. This study aims to examine the prospective association of sleep duration in infancy and early childhood with body composition and cardiometabolic health at 6 years of age.
Data were available for 5161 children from a population-based cohort in the Netherlands. Sleep duration was assessed at ages 2, 6, 24, and 36 months by parental reports. When children were 6 years old, measures of body composition (iDXA), blood pressure, insulin, and lipid levels were collected. Longitudinal associations among sleep duration, body composition, and cardiometabolic health were studied with multivariable linear regression analyses. In addition, potential bidirectional associations between sleep duration and BMI were studied by using cross-lagged modeling.
Shorter sleep duration at 2 months predicted higher BMI and fat mass in 6-year-old children, accounting for confounders and BMI at 2 months (e.g., for BMI, per hour sleep, B = -0.018, 95% CI = -0.026; -0.009). No temporal relationships among sleep duration at other ages, later body composition, and cardiometabolic outcomes were found. The cross-lagged model indicated a bidirectional association between sleep duration and BMI in early life (2 to 6 months of age).
Shorter sleep duration at 2 months, but not at later ages, predicted poorer body composition 6 years later. We found no clear evidence for an effect of sleep duration in early life on cardiometabolic health.
从中童年期开始，睡眠时间短与肥胖风险较高相关。然而，幼儿期的睡眠时间是否与身体成分和心脏代谢健康相关仍不清楚。本研究旨在探讨婴儿期和幼儿期的睡眠时间与6岁时的身体成分和心脏代谢健康之间的前瞻性关联。
荷兰一项基于人群的队列研究中有5161名儿童的数据。通过父母报告评估2、6、24和36个月大时的睡眠时间。当儿童6岁时，收集身体成分（iDXA）、血压、胰岛素和血脂水平的测量数据。采用多变量线性回归分析研究睡眠时间、身体成分和心脏代谢健康之间的纵向关联。此外，通过交叉滞后模型研究睡眠时间与BMI之间潜在的双向关联。
2个月时睡眠时间较短可预测6岁儿童的BMI和脂肪量较高，这在考虑了混杂因素和2个月时的BMI后依然成立（例如，对于BMI，每小时睡眠时间的B值为-0.018，95%CI为-0.026至-0.009）。未发现其他年龄段的睡眠时间与后期身体成分及心脏代谢结果之间存在时间关系。交叉滞后模型表明生命早期（2至6个月大）睡眠时间与BMI之间存在双向关联。
2个月时睡眠时间较短可预测6年后身体成分较差，但后期则不然。我们没有发现明确证据表明生命早期的睡眠时间对心脏代谢健康有影响。
