免疫血清预处理对小鼠肉瘤病毒（莫洛尼氏）肿瘤诱导及生长的影响。
Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
作者信息
Guiliani F, Casazza A M, Soranzo C, Di Marco A
出版信息
Br J Cancer. 1977 Feb;35(2):190-8. doi: 10.1038/bjc.1977.26.
Regressor serum from MSV-M-infected mice markedly reduced MSV-M oncogenesis when administered i.p. (0-1 ml/mouse) as much as 30 days before i.m. MSV-M infection in adult BALB/c mice. The regressor serum activity appeared to be directly dependent on the amount of IgG, as shown by: (1) inactivity of sera which have low virus-neutralizing antibody content; (2) high effectiveness only of the IgG serum fraction; (3) inactivity of regressor serum incubated with anti-mouse gamma-globulin serum. The regressor serum activity was specific and could not be ascribed to interferon or interferon-inducing factors, antigen-antibody complexes or free antigen. The activity was not suppressed by sublethal irradiation (380 rad) of recipient mice. These results suggest that the activity of regressor serum administered before MSV-M infection is mediated through sensitization of host cells which are not radiosensitive.
在成年BALB/c小鼠肌肉注射MSV-M感染前多达30天腹腔注射（0 - 1毫升/小鼠）时，来自感染MSV-M小鼠的回归血清显著降低了MSV-M致癌作用。回归血清活性似乎直接依赖于IgG的量，表现为：（1）病毒中和抗体含量低的血清无活性；（2）仅IgG血清组分高效；（3）与抗小鼠γ球蛋白血清孵育的回归血清无活性。回归血清活性具有特异性，不能归因于干扰素或干扰素诱导因子、抗原-抗体复合物或游离抗原。受体小鼠接受亚致死剂量照射（380拉德）不会抑制该活性。这些结果表明，在MSV-M感染前给予的回归血清活性是通过对不具有放射敏感性的宿主细胞进行致敏来介导的。
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