Brazhnikova M G, Konstantinova N V, Potapova N P, Tolstykh I V
Antibiotiki. 1977 Jun;22(6):486-9.
Nocamycin is produced by Nocardiopsis syringae. It is recovered from the culture fluid by extraction with chloroform. The molecular weight of the crystalline antibiotic is 503, its melting point is 147--149 degrees, [alpha]20 degrees D = --50 degrees (c. 0.21, chloroform), lambdamax235 and 348 nm(E1%sm= = 150 and 420), the summation formula is C26 H33NO9, the biological activity is 100000 Units/mg with respect to Bacillus mycoides. Nocamycin forms salts with alkalies soluble in water. On hydrolysis with an alkali it forms carbonic acid having no ester bond (IP spectrum) and methoxylic group present in the antibiotic molecule. Nocamycin is a new natural substance.
诺卡霉素由丁香诺卡氏菌产生。它通过用氯仿萃取从培养液中回收。结晶抗生素的分子量为503，熔点为147 - 149摄氏度，[α]20D = -50度（c. 0.21，氯仿），最大吸收波长为235和348纳米（E1%sm = 150和420），分子式为C26H33NO9，相对于蕈状芽孢杆菌的生物活性为100000单位/毫克。诺卡霉素与碱形成可溶于水的盐。用碱水解时，它形成没有酯键的碳酸（红外光谱）以及抗生素分子中存在的甲氧基。诺卡霉素是一种新的天然物质。
