[抗生素加耳他霉素。加耳他霉素酮的结构]
[The antibiotic galtamycin. The structure of galtamycinone].
作者信息
Murenets N V, Kudinova M K, Kliuev N A, Chernyshev A I, Shorshnev S V
出版信息
Antibiot Med Biotekhnol. 1986 Jun;31(6):431-4.
PMID:3017199
Abstract
The structure of galtamycinone, a chromophore moiety of galtamycin, a new antitumor antibiotic was determined by spectral analysis, i.e. UV, NMR and mass spectrometry. Galtamycinone was shown to be 1,4,6-trioxy-10 [4 (e), 5 (e)-dioxy-6 (e)-methyl-tetrahydropyran-2(e)-yl]-8-methyl tetracendion-5,12. It represents a new type of anthracycline chromophores containing a C-glycoside bond in its molecule.
摘要
通过光谱分析，即紫外光谱、核磁共振光谱和质谱，确定了新型抗肿瘤抗生素加耳他霉素的发色团部分加耳他霉素酮的结构。加耳他霉素酮被证明是1,4,6-三氧基-10 [4 (e), 5 (e)-二氧基-6 (e)-甲基-四氢吡喃-2(e)-基]-8-甲基十四碳二烯-5,12。它代表了一种在分子中含有C-糖苷键的新型蒽环类发色团。
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