一种通过一锅烯烃异构化-氧化反应裂解肽中酰胺氮上的烯丙基保护基的方法。
A method for cleaving an allyl protecting group at the amide nitrogen of peptides by one-pot olefin isomerization-oxidation.
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo 060-0812 Japan.
出版信息
J Org Chem. 2008 Dec 5;73(23):9494-6. doi: 10.1021/jo801915c.
PMID:18980332
Abstract
A facile method for N-deallylation at the amide nitrogen of peptides is described. One-pot deallylation of a substrate through ruthenium hydride-catalyzed terminal olefin isomerization and subsequent ozonolysis gave the corresponding deallylated product under mild conditions.
摘要
描述了一种在肽的酰胺氮上进行 N-脱烯丙基化的简便方法。通过钌氢催化末端烯烃异构化和随后的臭氧化，在温和条件下一锅法脱烯丙基化底物，得到相应的脱烯丙基产物。
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