烯胺酮的 Vilsmeier 反应：高效合成卤代吡啶-2(1H)-酮。
Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones.
机构信息
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
出版信息
J Org Chem. 2008 Dec 5;73(23):9504-7. doi: 10.1021/jo801959j.
PMID:19006368
Abstract
A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
摘要
本文描述了一种在 Vilsmeier 条件下，由一系列易得的烯胺酮一锅法高效合成卤代吡啶-2(1H)-酮的方法，并提出了一个涉及顺序卤化、甲酰化和分子内亲核环化的反应机制。
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