Mamun A A, Hayatbakhsh M R, O'Callaghan M, Williams G, Najman J
School of Population Health, University of Queensland, Herston Road, Herston, Brisbane, Queensland 4006, Australia.
Int J Obes (Lond). 2009 Jan;33(1):14-20. doi: 10.1038/ijo.2008.220. Epub 2008 Nov 4.
Objectives of this study were to examine the prospective association of childhood body mass index (BMI) and overweight and pubertal stages with BMI and overweight in early adulthood independent of each other.
A population-based prospective birth cohort.
We used a population-based prospective birth cohort of 2897 (52% men) young adults who were born during 1981-1983 in Brisbane, Australia, and for whom we had puberty stages using Tanner scale at 14 years and measured BMI at 5 years of age.
Pubertal stages at adolescent and BMI and its categories at 21 years.
We found that increasing BMI and overweight at 5 years of age predict the advanced stages of puberty. An advanced stage of puberty predicts young adults' BMI and overweight status at 21 years. When taking both childhood BMI and pubertal status into consideration, we found that being overweight at 5 years substantively increases BMI at 21 years, regardless of the stage of puberty reported at 14 years. We also found that subjects with normal BMI at 5 years but with higher stages of puberty at 14 years had threefold greater risk to be overweight at 21 years compared with their counterparts. All associations remained consistent after controlling for potential confounders.
Although this study underscores the impact of both child overweight and pubertal development on young adults' obesity, the mechanism that further explains the impact of puberty needs to be identified.
本研究的目的是分别考察儿童体重指数（BMI）及超重情况与青春期阶段，对成年早期BMI及超重情况的前瞻性关联。
一项基于人群的前瞻性出生队列研究。
我们使用了一个基于人群的前瞻性出生队列，该队列包含2897名（52%为男性）年轻成年人，他们于1981年至1983年出生在澳大利亚布里斯班，我们掌握他们14岁时用坦纳量表评估的青春期阶段，以及5岁时测量的BMI。
青少年时期的青春期阶段以及21岁时的BMI及其分类。
我们发现，5岁时BMI增加及超重预示着青春期的进展阶段。青春期进展阶段预示着21岁时年轻成年人的BMI及超重状况。当同时考虑儿童期BMI和青春期状态时，我们发现，5岁时超重会显著增加21岁时的BMI，无论14岁时报告的青春期处于哪个阶段。我们还发现，5岁时BMI正常但14岁时青春期阶段较高的受试者，在21岁时超重的风险是其同龄人（5岁时BMI正常且14岁时青春期阶段较低）的三倍。在控制潜在混杂因素后，所有关联仍然一致。
尽管本研究强调了儿童超重和青春期发育对年轻成年人肥胖的影响，但仍需确定进一步解释青春期影响的机制。
