Institute of Cancer, Barts and the London School of Medicine & Dentistry, London, UK.
HPB (Oxford). 2008;10(5):327-31. doi: 10.1080/13651820802007464.
Ethnic background and geographical location are important when measuring the incidence of gallbladder carcinoma leading to variable mortality rates across the world.
Age standardized mortality rates [ASR(W)] were extracted separately for males and females from a database maintained by the International Agency for Research on Cancer for 50 countries across the world (Europe 32; the Americas 8; and Asia 10) for the period 1992-2002 and log-linear regression was performed to analyse trends in the last decade.
In the period 1992-2002, declining trends in mortality for both sexes were observed in Germany, Sweden, Japan, USA, and Hungary (p<0.001), and in France, Canada, United Kingdom, The Netherlands, and Hong Kong (p<0.01). Austria, Czechoslovakia, Slovenia, Denmark, Spain, and Israel exhibited decreasing mortality trends more significant in women (p<0.01) than in men (p<0.05). Decreasing female mortality trends were seen in Finland, Italy, and Portugal (p<0.01) and in Georgia, Luxembourg, and Belgium (p<0.05). Iceland, Costa Rica, and Korea were the only countries with an increase in male mortality (p<0.05).
Overall, there was a decline in ASR(W) for gallbladder cancer. Better diagnostic modalities resulting in appropriate staging of gallbladder/biliary cancers, as well as changes in the ICD classification and perhaps increased awareness, may have contributed to these trends.
在衡量胆囊癌的发病率时，种族背景和地理位置非常重要，这导致了全球死亡率的差异。
从国际癌症研究机构维护的数据库中分别提取了欧洲 32 个国家、美洲 8 个国家和亚洲 10 个国家 1992-2002 年间的男性和女性年龄标准化死亡率（ASR(W)）数据，并进行对数线性回归分析以探讨过去 10 年的趋势。
在 1992-2002 年期间，德国、瑞典、日本、美国和匈牙利的男女死亡率均呈下降趋势（p<0.001），法国、加拿大、英国、荷兰和中国香港的男女死亡率也呈下降趋势（p<0.01）。奥地利、捷克斯洛伐克、斯洛文尼亚、丹麦、西班牙和以色列的女性死亡率下降趋势更为显著（p<0.01），而男性死亡率下降趋势则不明显（p<0.05）。芬兰、意大利和葡萄牙的女性死亡率呈下降趋势（p<0.01），格鲁吉亚、卢森堡和比利时的女性死亡率呈下降趋势（p<0.05）。冰岛、哥斯达黎加和韩国是男性死亡率唯一上升的国家（p<0.05）。
总体而言，胆囊癌的 ASR(W)呈下降趋势。更好的诊断方法导致胆囊/胆道癌的分期更为准确，以及 ICD 分类的变化，也许还有意识的提高，可能促成了这些趋势。
