Burns J W, Werchan P M, Fanton J W, Dollins A B
Crew Technology Division, USAFSAM, Brooks AFB, TX 78235-5301.
Aviat Space Environ Med. 1991 Jul;62(7):615-7.
Seven male baboons (average weight, 20.6 kg) were trained in a simple shock-avoidance performance task on the USAFSAM centrifuge. A red light was presented to the baboon at approximate 2-s intervals. The animal was allowed 1 s to turn off the light or receive a 1-s shock. The shock could be abbreviated by a late trigger pull. Thus, the animal could avoid, escape, or accept the full shock. EEG was monitored from three transcranial stainless steel electrodes. Loss of consciousness (LOC) was induced by a rapid onset (4 or 6/s) exposure to 8 +Gz and sustained until LOC was identified by a near isoelectric EEG signal. Performance recovery time was measured from the return of EEG activity to the time when the animal resumed the performance task. These data were compared with previously obtained human data and found to be very similar. Also, it was found that time of performance recovery became significantly shorter after multiple LOC exposures and the performance recovery time significantly increased with increased time of unconsciousness. This study demonstrates the utility of the baboon as an animal model for G-induced LOC (G-LOC) research.
七只雄性狒狒（平均体重20.6千克）在美国空军航天医学学校（USAFSAM）的离心机上接受简单的电击回避性能任务训练。每隔约2秒向狒狒呈现一次红灯。动物有1秒钟时间关闭灯光，否则将接受1秒钟的电击。电击可通过延迟触发拉动而缩短。因此，动物可以避免、逃脱或接受全部电击。通过三个经颅不锈钢电极监测脑电图（EEG）。通过快速施加（4或6次/秒）8 +Gz使其失去意识（LOC），并持续到通过接近等电位的EEG信号确定失去意识。性能恢复时间从EEG活动恢复到动物重新开始执行任务的时间进行测量。这些数据与之前获得的人类数据进行比较，发现非常相似。此外，还发现多次失去意识暴露后，性能恢复时间显著缩短，且性能恢复时间随无意识时间的增加而显著增加。这项研究证明了狒狒作为重力诱发失去意识（G-LOC）研究动物模型的实用性。
