笼状分子篮内客体分子的包结：热力学与选择性。

Encapsulation of guests within a gated molecular basket: thermodynamics and selectivity.

机构信息

Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.

出版信息

Org Lett. 2008 Dec 4;10(23):5361-4. doi: 10.1021/ol802199t.

Abstract

Molecular basket 1 has been designed to contain a set of aromatic gates, each with rotational mobility restricted via intramolecular hydrogen bonding. This structural, yet dynamic, feature of the host has been revealed to permit the formation of a transient enclosed space capable of containing haloalkanes, whose size/shape, electronic and entropic attributes contributed to the thermodynamics of binding. Markedly, the basket is capable of mediating the trafficking of a broad range of molecules.

摘要

分子篮 1 被设计用来容纳一组芳香族门，每个门的旋转流动性都通过分子内氢键来限制。这种结构上的，但动态的，宿主的特征被揭示出来，允许形成一个暂时的封闭空间，能够容纳卤代烷烃，其大小/形状、电子和熵属性有助于结合的热力学。值得注意的是，篮子能够介导广泛的分子的运输。