色素沉着的PAX途径：Pax3在黑色素生成、黑素细胞干细胞维持及疾病中的作用
Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease.
作者信息
Kubic Jennifer D, Young Kacey P, Plummer Rebecca S, Ludvik Anton E, Lang Deborah
机构信息
Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
出版信息
Pigment Cell Melanoma Res. 2008 Dec;21(6):627-45. doi: 10.1111/j.1755-148X.2008.00514.x.
Abstract
Transcription factors initiate programs of gene expression and are catalysts in downstream molecular cascades that modulate a variety of cellular processes. Pax3 is a transcription factor that is important in the melanocyte and influences melanocytic proliferation, resistance to apoptosis, migration, lineage specificity and differentiation. In this review, we focus on Pax3 and the molecular pathways that Pax3 is a part of during melanogenesis and in the melanocyte stem cell. These roles of Pax3 are emphasized during the development of diseases and syndromes resulting from either too much or too little Pax3 function. Due to its key task in melanocyte stem cells and tumors, the Pax3 pathway may provide an ideal target for either stem cell or cancer therapies.
摘要
转录因子启动基因表达程序，是下游分子级联反应中的催化剂，可调节多种细胞过程。Pax3是一种转录因子，在黑素细胞中起重要作用，影响黑素细胞的增殖、抗凋亡能力、迁移、谱系特异性和分化。在本综述中，我们重点关注Pax3以及Pax3在黑素生成和黑素细胞干细胞中所参与的分子途径。在因Pax3功能过多或过少导致的疾病和综合征的发展过程中，Pax3的这些作用得到了强调。由于其在黑素细胞干细胞和肿瘤中的关键作用，Pax3途径可能为干细胞治疗或癌症治疗提供理想的靶点。
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