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[使用Dynesys系统进行动态稳定和非融合性加压治疗退行性腰椎滑脱:25例前瞻性研究系列]

[Dynamic stabilisation and compression without fusion using Dynesys for the treatment of degenerative lumbar spondylolisthesis: a prospective series of 25 cases].

作者信息

Ricart O, Serwier J-M

机构信息

Service orthopedie-traumatologie, clinique Ambroise-Paré, 21, route de Guentrange, 57100 Thionville, France.

出版信息

Rev Chir Orthop Reparatrice Appar Mot. 2008 Nov;94(7):619-27. doi: 10.1016/j.rco.2008.04.015. Epub 2008 Aug 23.

Abstract

PURPOSE OF THE STUDY

We used the Dynesys stabilization to treat degenerative lumber spondylolysis by decompression without fusion with the objective of decreasing the morbidity related to instrumented arthrodesis in older patients yet preventing progression of the displacement.

MATERIAL AND METHODS

This was a prospective study of 25 patients with symptomatic degenerative lumber spondylolysis associated with degenerative spinal canal stenosis documented by saccoradiculography. For inclusion, static anteroposterior intervertebral displacement had to be at least 3mm in the upright position, irrespective of the displacement on the stress films. The series included 19 women and six men, mean age 71 years (range 53-83). The level was L4-L5 in all 25 cases. Instrumentations involved a single level (L4-L5) or two levels (L3-L5). All patients were explored with computed tomography and saccoradiculography. An MRI was obtained in 12 patients. Pre- and postoperative stress images and views of the entire spinal column in the upright position were used to study pelvic parameters and sagittal spinal balance before and after surgery. Lumbar incidence and lordosis was used to divide the patients into three groups. Outcome was assessed with the Beaujon classification at minimal follow-up of 24 months, mean 34, range 24-72 months.

RESULTS

Very good results were obtained in 72% of patients (relative gain greater than 70%) and good results in 28% (relative gain 40-70%). There were not outcomes considered fair or poor. There were two complications: aggravation of preoperative crural paresia with complete recovery and replacement of one neuroaggressive pedicular screw with no consequence thereafter. The stress films confirmed the residual mobility of the instrumented level when the preserved disc was of sufficient height. Postoperative pelvic parameters after Dynesys instrumentation showed improvement in sagittal tilt for T9 by accentuated suprajacent lordosis, even in the event of anterior spinal imbalance preoperatively.

DISCUSSION

Theoretically, solicitation of the pedicular anchors of a rigid instrumentation on a poorly balanced spine would rapidly lead to failure, while fibrous non-union on a globally well balanced spine would be tolerated much longer or even definitively without development of clinical symptoms. In our opinion, the Dynesys instrumentation enables a real restabilization of the spine by adapting to the patients particular spinal balance intra-operatively and postoperatively without imposing a definitive curvature as would a rigid fixation. The ultimate objective is to accompany the aging spine without brutally changing the stress forces. This semi-rigid instrumentation without fusion enables an adapted evolution of the overall spinal degeneration without imposing excessive local forces, which could be sources of stenosis or junctional instability.

CONCLUSION

The most logical indication for this instrumentation is the older subject aged at least 65 years with degenerative lumber spondylolysis and a predominantly self-reducible angular displacement and satisfactory disc height. This context (group 3 in our series) occurs in patients with a weak sacral slope and incidence, as well as minimal lordosis adapted to the pelvic parameters. The Dynesys instrumentation can be a palliative alternative to fusion for more advanced degenerative lumber spondylolysis occurring on spines with anterior imbalance where fusion would be technically difficult in terms of correction of the kyphosis or because of the general risk factors.

摘要

研究目的

我们采用Dynesys固定系统治疗退行性腰椎峡部裂,通过减压而非融合手术,旨在降低老年患者因器械辅助融合手术导致的发病率,同时防止移位进展。

材料与方法

这是一项针对25例有症状的退行性腰椎峡部裂患者的前瞻性研究,这些患者伴有经脊髓造影证实的退行性椎管狭窄。纳入标准为,无论应力位片上的移位情况如何,站立位时静态前后位椎间移位至少为3mm。该组包括19名女性和6名男性,平均年龄71岁(范围53 - 83岁)。所有25例患者的病变节段均为L4 - L5。手术器械涉及一个节段(L4 - L5)或两个节段(L3 - L5)。所有患者均接受了计算机断层扫描和脊髓造影检查。12例患者进行了磁共振成像检查。术前和术后的应力位影像以及站立位全脊柱影像用于研究手术前后的骨盆参数和矢状面脊柱平衡。根据腰椎前凸角和腰椎前凸将患者分为三组。在至少24个月的最短随访期(平均34个月,范围24 - 72个月)时,采用Beaujon分类法评估结果。

结果

72%的患者获得了非常好的结果(相对改善率大于70%),28%的患者获得了好的结果(相对改善率40 - 70%)。没有结果被认为是一般或差的。发生了2例并发症:术前小腿轻瘫加重但完全恢复,以及1枚侵袭神经的椎弓根螺钉被替换,此后未产生不良后果。当保留的椎间盘高度足够时,应力位片证实了器械固定节段的残余活动度。Dynesys器械固定术后的骨盆参数显示,即使术前存在脊柱前凸失衡,T9的矢状面倾斜度也因上位节段明显的前凸增加而得到改善。

讨论

从理论上讲,在失衡的脊柱上对刚性内固定器械的椎弓根锚定施加应力会迅速导致失败,而在整体平衡良好的脊柱上,纤维性骨不连可能会被耐受更长时间甚至最终不会出现临床症状。我们认为,Dynesys器械固定系统能够通过在术中及术后适应患者特定的脊柱平衡,实现脊柱的真正再稳定,而不像刚性固定那样强制形成确定的曲度。最终目标是伴随脊柱老化,而不粗暴地改变应力。这种非融合的半刚性器械固定能够使整个脊柱退变适应性发展,而不施加可能导致狭窄或节段性不稳定的过度局部应力。

结论

这种器械固定最合理的适应证是年龄至少65岁、患有退行性腰椎峡部裂、主要为可自行复位的角位移且椎间盘高度满意的老年患者。这种情况(我们系列中的第3组)见于骶骨倾斜度和前凸角较小、且腰椎前凸与骨盆参数相适应的患者。对于更严重的退行性腰椎峡部裂,当脊柱存在前凸失衡,融合手术在技术上难以纠正后凸畸形或因存在一般风险因素时,Dynesys器械固定可以作为融合手术的一种姑息性替代方案。

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