Stagnaro-Green Alex
Touro University College of Medicine, Hackensack, New Jersey 07601, USA.
J Clin Endocrinol Metab. 2009 Jan;94(1):21-5. doi: 10.1210/jc.2008-1288. Epub 2008 Nov 4.
Preterm delivery is the leading cause of perinatal morbidity and mortality in the United States, and its incidence is increasing. The present manuscript reviews the literature on the relationship of hypothyroidism and/or autoimmune thyroid disease to preterm delivery.
A PubMed search was used to identify all relevant articles. A reference search of all retrieved articles was undertaken. All articles identified in the search were included in the review.
Uncontrolled case series were discussed in the manuscript but not included in drawing conclusions from the literature.
Hypothyroidism and autoimmune thyroid disease in euthyroid women are associated with preterm delivery. A single intervention trial has documented a dramatic decrease in the incidence of preterm delivery in thyroid antibody-positive women treated with levothyroxine. Confirmatory studies are needed before universal screening and intervention can be recommended.
在美国，早产是围产期发病和死亡的主要原因，且其发生率正在上升。本手稿综述了关于甲状腺功能减退症和/或自身免疫性甲状腺疾病与早产关系的文献。
使用PubMed搜索来识别所有相关文章。对所有检索到的文章进行参考文献搜索。搜索中识别出的所有文章均纳入综述。
手稿中讨论了非对照病例系列，但在从文献得出结论时未将其纳入。
甲状腺功能正常的女性中，甲状腺功能减退症和自身免疫性甲状腺疾病与早产有关。一项单一的干预试验记录了用左甲状腺素治疗的甲状腺抗体阳性女性早产发生率显著下降。在推荐进行普遍筛查和干预之前，需要进行确证性研究。
