肾素-血管紧张素系统基因中的遗传变异与墨西哥裔美国人的心血管-肾脏相关危险因素有关。
Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans.
作者信息
Thameem Farook, Voruganti V Saroja, He Xin, Nath Subrata D, Blangero John, MacCluer Jean W, Comuzzie Anthony G, Abboud Hanna E, Arar Nedal H
机构信息
Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
出版信息
Hum Genet. 2008 Dec;124(5):557-9. doi: 10.1007/s00439-008-0581-x. Epub 2008 Nov 6.
Abstract
The aim of this study is to examine whether the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms of the renin-angiotensin system (RAS) genes are associated with cardiovascular and renal-related risk factors in Mexican Americans. Study participants (N = 848) were genotyped by Taqman assays. Association analyses were performed by measured genotype approach. Of the phenotypes examined, the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms exhibited significant association with systolic blood pressure, glomerular filtration rate and body mass index, respectively. The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease.
摘要
本研究的目的是检验肾素 - 血管紧张素系统（RAS）基因的ACE - I/D、AGT - M235T和AT1R - A1166C多态性是否与墨西哥裔美国人的心血管和肾脏相关危险因素有关。研究参与者（N = 848）通过Taqman分析进行基因分型。采用测量基因型方法进行关联分析。在所检查的表型中，ACE - I/D、AGT - M235T和AT1R - A1166C多态性分别与收缩压、肾小球滤过率和体重指数显著相关。数据表明，RAS中检测的多态性可能调节与心血管 - 肾脏疾病相关的危险因素。
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