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本文引用的文献

1
Population-based case-control study of renin-angiotensin system genes polymorphisms and hypertension among Hispanics.基于人群的西班牙裔肾素-血管紧张素系统基因多态性与高血压病例对照研究。
Hypertens Res. 2008 Mar;31(3):401-8. doi: 10.1291/hypres.31.401.
2
A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS.在一个基于社区的样本（SAFHS）中进行全基因组连锁分析以寻找与慢性肾脏病的关联。
Nephrol Dial Transplant. 2008 Oct;23(10):3184-91. doi: 10.1093/ndt/gfn215. Epub 2008 Apr 28.
3
Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study.2型糖尿病患者肾功能和蛋白尿的全基因组连锁扫描：糖尿病心脏研究
Diabet Med. 2008 Mar;25(3):268-76. doi: 10.1111/j.1464-5491.2007.02361.x.
4
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND).多民族糖尿病患者群体中估算肾小球滤过率的全基因组扫描：肾病与糖尿病家族研究（FIND）
Diabetes. 2008 Jan;57(1):235-43. doi: 10.2337/db07-0313. Epub 2007 Nov 14.
5
Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans.在墨西哥裔美国人中，基因型与糖尿病的相互作用对肾小球滤过率与2号染色体q区域连锁检测的影响。
Diabetes. 2007 Nov;56(11):2818-28. doi: 10.2337/db06-0984. Epub 2007 Aug 13.
6
The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification.数量性状连锁不平衡检验：在不存在群体分层的情况下，比数量传递不平衡检验更具效力的替代方法。
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S91. doi: 10.1186/1471-2156-6-S1-S91.
7
Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.原发性高血压中肾素-血管紧张素-醛固酮系统的基因多态性与肾功能不全
J Hypertens. 2005 Feb;23(2):309-16. doi: 10.1097/00004872-200502000-00013.
8
The impact of renin-angiotensin system polymorphisms on physiological and pathophysiological processes in humans.肾素-血管紧张素系统基因多态性对人类生理和病理生理过程的影响。
Curr Opin Nephrol Hypertens. 2004 Jan;13(1):101-6. doi: 10.1097/00041552-200401000-00014.
9
Exploring positional candidate genes: linkage conditional on measured genotype.探索定位候选基因：基于测量基因型的连锁分析
Behav Genet. 2004 Mar;34(2):173-7. doi: 10.1023/B:BEGE.0000013731.03827.69.
10
Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease.终末期肾病中肾素-血管紧张素-醛固酮系统的基因多态性
Kidney Int. 2001 Jul;60(1):46-54. doi: 10.1046/j.1523-1755.2001.00769.x.

肾素-血管紧张素系统基因中的遗传变异与墨西哥裔美国人的心血管-肾脏相关危险因素有关。

Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans.

作者信息

Thameem Farook, Voruganti V Saroja, He Xin, Nath Subrata D, Blangero John, MacCluer Jean W, Comuzzie Anthony G, Abboud Hanna E, Arar Nedal H

机构信息

Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

出版信息

Hum Genet. 2008 Dec;124(5):557-9. doi: 10.1007/s00439-008-0581-x. Epub 2008 Nov 6.

DOI:10.1007/s00439-008-0581-x
PMID:18985387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2785727/
Abstract

The aim of this study is to examine whether the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms of the renin-angiotensin system (RAS) genes are associated with cardiovascular and renal-related risk factors in Mexican Americans. Study participants (N = 848) were genotyped by Taqman assays. Association analyses were performed by measured genotype approach. Of the phenotypes examined, the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms exhibited significant association with systolic blood pressure, glomerular filtration rate and body mass index, respectively. The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease.

摘要

本研究的目的是检验肾素 - 血管紧张素系统（RAS）基因的ACE - I/D、AGT - M235T和AT1R - A1166C多态性是否与墨西哥裔美国人的心血管和肾脏相关危险因素有关。研究参与者（N = 848）通过Taqman分析进行基因分型。采用测量基因型方法进行关联分析。在所检查的表型中，ACE - I/D、AGT - M235T和AT1R - A1166C多态性分别与收缩压、肾小球滤过率和体重指数显著相关。数据表明，RAS中检测的多态性可能调节与心血管 - 肾脏疾病相关的危险因素。