Alekhina R P, Likhtenshteĭn A V, Shapot V S
Biull Eksp Biol Med. 1976;82(11):1354-7.
The relative content of poly(A)-RNA in the cytoplasm was greater in the cells of Zajdela hepatoma and the liver of tumour-bearing rats than in the normal hepatocytes of rats. Besides, the tumour cells (and to a lesser extent the hepatocytes of the tumour-bearing animal) were characterized by the changes in the ratio of the polyribosomes and monoribosomes usual for normal hepatocytes (and correspondingly between the m-RNP-particles and the informosomes) in favour of the latter, this pointing to definite changes in their protein-synthesizing apparatus. As judged by some of the parameters, the cells of the tumour-bearing by some of the parameters, the cells of the tumour-bearing animal occupied an intermediate position between the normal and tumour cells.
Zajdela肝癌细胞和荷瘤大鼠肝脏细胞胞质中多聚腺苷酸RNA（poly(A)-RNA）的相对含量高于正常大鼠肝细胞。此外，肿瘤细胞（荷瘤动物的肝细胞程度较轻）的特征是，正常肝细胞中常见的多核糖体与单核糖体比例（相应地，信使核糖核蛋白颗粒与信息体之间的比例）发生变化，有利于后者，这表明其蛋白质合成装置发生了一定变化。从某些参数判断，荷瘤动物的细胞在某些参数上介于正常细胞和肿瘤细胞之间。
