Ctirad Andrys, Lenka Borska, David Pohl, Zdenek Fiala, Kveta Hamakova, Karel Ettler, Jan Krejsek
Department of Clinical Immunology and Allergy, Charles University, Prague, Czech Republic.
Int J Dermatol. 2008 Oct;47(10):1011-4. doi: 10.1111/j.1365-4632.2008.03666.x.
Goeckerman's therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. Pentraxin 3 (PTX3) is a newly identified acute phase reactant with non redundant functions in innate immunity. PTX3 has been shown to be a reliable prognostic marker in patients with various inflammatory disorders including rheumatoid arthritis, vasculitis, and psoriasis.
The aim of this study was to evaluate the influence of Goeckerman's therapy of psoriasis on levels of two pentraxins: long pentraxin PTX3 and C reactive protein in 49 patients with chronic plaque psoriasis. CRP was assessed by immunonephelometry on IMMAGE 800 (Beckman, USA). PTX3 was detected using sandwich ELISA detection set (Alexis Biochemicals, Switzerland).
The serum levels of both parameters (expressed as average +/- 1 SD) were significantly diminished after GT. The level of PTX3 dropped from 1.92 +/- 0.72 ng/ml before GT to 1.66 +/- 0.58 ng/ml after GT (P= 0.0396) and the level of CRP fell from 4.64 +/- 3.93 mg/l to 1.66 +/- 0.58 mg/l (P < 0.0001).Comparing to healthy controls, the serum levels of both parameters before GT were significantly higher than those found in healthy blood donors and remained significantly increased after GT.
Increased serum concentrations of pentraxin 3 and CRP are alleviated by GT in patients with psoriasis.
戈克曼银屑病疗法（GT）基于每日在患部皮肤涂抹药用级煤焦油，随后接受紫外线照射。五聚素3（PTX3）是一种新发现的急性期反应物，在固有免疫中具有非冗余功能。PTX3已被证明是包括类风湿关节炎、血管炎和银屑病在内的各种炎症性疾病患者的可靠预后标志物。
本研究旨在评估戈克曼银屑病疗法对49例慢性斑块状银屑病患者的两种五聚素水平的影响：长链五聚素PTX3和C反应蛋白。采用免疫比浊法在IMMAGE 800（美国贝克曼公司）上检测CRP。使用夹心ELISA检测试剂盒（瑞士Alexis Biochemicals公司）检测PTX3。
GT治疗后，两个参数的血清水平（以平均值±1标准差表示）均显著降低。PTX3水平从GT治疗前的1.92±0.72 ng/ml降至GT治疗后的1.66±0.58 ng/ml（P = 0.0396），CRP水平从4.64±3.93 mg/l降至1.66±0.58 mg/l（P < 0.0001）。与健康对照组相比，GT治疗前两个参数的血清水平均显著高于健康献血者，且GT治疗后仍显著升高。
GT可降低银屑病患者血清中五聚素3和CRP的浓度。
