Baran Anna, Stepaniuk Anna, Kiluk Paulina, Kaminski Tomasz W, Maciaszek Magdalena, Flisiak Iwona
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland.
Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Metabolites. 2022 Jun 22;12(7):580. doi: 10.3390/metabo12070580.
Psoriasis is a systemic disease that is linked to cardiometabolic complications. Paraoxonase 1 (PON1) exerts anti-atherogenic properties. Pentraxin 3 (PTX3) is related to heart failure and atherosclerosis. We aimed to evaluate the protein levels in psoriatic patients and explore possible relations with disease activity, metaflammation parameters and systemic treatment. Thirty-three patients with plaque-type psoriasis and eleven healthy controls were enrolled in the study. Blood samples were collected before and after three months of therapy with acitretin or methotrexate. Serum proteins levels were evaluated using Bio-Plex 200 System. The mean serum pentraxin 3 level was significantly higher in patients with psoriasis, compared to controls (p < 0.01). Significant negative correlations between PTX3 with triglycerides in overweight patients, with glucose, cholesterol and triglycerides in obese patients, and with cholesterol and triglycerides in severe psoriatics were noted (all p < 0.05). After the treatment, PTX3 significantly decreased (p < 0.05). The mean serum PON1 in psoriatic patients did not differ, compared to the controls (p > 0.05). In psoriatics of normal weight, PON1 correlated negatively with liver enzymes activity (p < 0.05). PTX3 might exert a protective role in terms of cardiometabolic disorders development, especially in overweight and obese or most severe psoriatics. PON1 could serve as an indicator of the liver disorders in psoriasis.
银屑病是一种与心脏代谢并发症相关的全身性疾病。对氧磷酶1（PON1）具有抗动脉粥样硬化特性。五聚素3（PTX3）与心力衰竭和动脉粥样硬化有关。我们旨在评估银屑病患者的蛋白质水平，并探讨其与疾病活动、代谢性炎症参数和全身治疗之间的可能关系。本研究纳入了33例斑块型银屑病患者和11名健康对照者。在使用阿维A或甲氨蝶呤治疗三个月前后采集血样。使用Bio-Plex 200系统评估血清蛋白水平。与对照组相比，银屑病患者的血清五聚素3平均水平显著更高（p < 0.01）。在超重患者中，PTX3与甘油三酯之间存在显著负相关；在肥胖患者中，PTX3与血糖、胆固醇和甘油三酯之间存在显著负相关；在重度银屑病患者中，PTX3与胆固醇和甘油三酯之间存在显著负相关（所有p < 0.05）。治疗后，PTX3显著降低（p < 0.05）。与对照组相比，银屑病患者的血清PON1平均水平无差异（p > 0.05）。在体重正常的银屑病患者中，PON1与肝酶活性呈负相关（p < 0.05）。PTX3可能在心脏代谢紊乱的发展中发挥保护作用，尤其是在超重、肥胖或最严重的银屑病患者中。PON1可作为银屑病患者肝脏疾病的一个指标。
