Habibi Mohammadali, Mortazavi Hossein, Shadianloo Shervin, Balighi Kamran, Ghodsi S Zahra, Daneshpazhooh Maryam, Valikhani Mahin, Ghassabian Akhgar, Pooli Aydin H, Chams-Davatchi Cheyda
Department of Dermatology, Pemphigus Research Unit, Razi Hospital, Tehran University for Medical Sciences, Tehran, Iran.
Int J Dermatol. 2008 Nov;47(11):1141-4. doi: 10.1111/j.1365-4632.2008.03796.x.
The frequency and types of nail changes in pemphigus vulgaris (PV) are unclear. Aim To determine the frequency and types of nail changes, and their correlation with the number of skin and periungual bullae.
Seventy-nine patients with PV, including 59 new patients and 20 patients in relapse, were entered into the study. Microscopic examination in potassium hydroxide and culture for fungus were performed on all clinically abnormal nails.
Twenty-five (31.6%) of 79 patients showed nail changes, with paronychia (n = 8) and onychomadesis (n = 6) being the most common. One patient in relapse had onychomycosis. The frequency of nail changes in fingers affected by periungual bullae was significantly higher than in other fingers (P < 0.05). The number of nail changes was higher in patients with a larger number of skin bullae and in those with a longer duration of disease (P < 0.05).
Nail changes in PV are common and related to the number of skin bullae and the presence of periungual bullae.
寻常型天疱疮（PV）指甲改变的频率和类型尚不清楚。目的：确定指甲改变的频率和类型，以及它们与皮肤和甲周水疱数量的相关性。
79例PV患者纳入研究，其中59例为新发病例，20例为复发患者。对所有临床异常指甲进行氢氧化钾显微镜检查和真菌培养。
79例患者中有25例（31.6%）出现指甲改变，其中甲沟炎（n = 8）和甲脱（n = 6）最为常见。1例复发患者患有甲癣。受甲周水疱影响手指的指甲改变频率显著高于其他手指（P < 0.05）。皮肤水疱数量较多和病程较长的患者的指甲改变数量较多（P < 0.05）。
PV患者的指甲改变很常见，且与皮肤水疱数量和甲周水疱的存在有关。
