van Tuyll van Serooskerken Anne-Moon, Mosterd Klara, Veraart Joep C, Vermeer Maarten H, Frank Jorge, van Marion Ariënne M W
Department of Dermatology, University Medical Center Maastricht, The Netherlands.
Int J Dermatol. 2008 Nov;47 Suppl 1:21-4. doi: 10.1111/j.1365-4632.2008.03953.x.
Primary cutaneous follicle center lymphoma (PCFCL) is a neoplasm with differentiation of centrocytes and centroblasts presenting in the skin. At the time of initial manifestation, extracutaneous involvement is absent. PCFCL is considered as an indolent variant of primary cutaneous B-cell lymphomas since dissemination to extracutaneous sites is rare and the prognosis is favorable. Here we describe a 30-year-old man who was diagnosed with a cutaneous FCL and did not show extracutaneous affection at the time of occurrence. Six months later, however, he developed a diffuse large B-cell non-Hodgkin lymphoma localized in several lymph nodes of the neck that most likely reflects the occurrence of a second primary tumor in the same patient.
原发性皮肤滤泡中心淋巴瘤（PCFCL）是一种起源于皮肤的、具有中心细胞和中心母细胞分化特征的肿瘤。在疾病初发时，无皮肤外受累情况。由于皮肤外播散罕见且预后良好，PCFCL被认为是原发性皮肤B细胞淋巴瘤的一种惰性亚型。在此，我们描述一名30岁男性，其被诊断为皮肤滤泡中心淋巴瘤，发病时无皮肤外病变。然而，6个月后，他出现了弥漫性大B细胞非霍奇金淋巴瘤，病变局限于颈部多个淋巴结，这很可能提示同一患者发生了第二种原发性肿瘤。
