Sterneberg-Vos Heleen, van Marion Arienne M W, Frank Jorge, Poblete-Gutierrez Pamela
Department of Dermatology, and Maastricht University Center for Molecular Dermatology, University Medical Center Maastricht, The Netherlands.
Int J Dermatol. 2008 Nov;47 Suppl 1:38-41. doi: 10.1111/j.1365-4632.2008.03958.x.
Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities. The diagnosis is based on the clinical appearance in association with the typical histologic features of orthohyperkeratosis and a subepidermal band-like infiltrate. Treatment is difficult and rarely fully effective. We report on a woman with Flegel's disease who responded to a topical corticosteroid therapy with betamethasone dipropionate.
弗勒格尔病，又称持久性豆状角化过度症，是一种罕见的皮肤病，其特征为通常位于下肢的小红褐色角化过度丘疹。诊断基于临床表现以及正角化过度和表皮下带状浸润的典型组织学特征。治疗困难，很少能完全有效。我们报告了一名患有弗勒格尔病的女性，她对丙酸倍他米松局部皮质类固醇治疗有反应。
