Kuokkanen K, Alavaikko M, Pitkänen R
Acta Derm Venereol. 1983;63(4):357-60.
A 62-year-old female with a 20-year history of small horny papules on the skin of the legs is described. Light microscopy revealed a hyperkeratotic papule with atrophic epidermis and a dense dermal inflammatory cell infiltrate with many cerebriform lymphocytes not earlier described in connection with hyperkeratosis lenticularis perstans (HLP). The electron-microscopic picture showed membrane-coating granules (MCG) and keratohyalin located in different cells, indicating that the disorder of keratinization in HLP is possibly caused by reduced co-operation between these cells and that the keratinization process occurs in the absence of MCG. Perpetual treatment with oral retinoid was successful.
本文描述了一位62岁女性，其腿部皮肤出现小角质丘疹已有20年病史。光镜检查显示为角化过度性丘疹，伴有萎缩性表皮和密集的真皮炎性细胞浸润，其中有许多脑回状淋巴细胞，这在以往关于持久性豆状角化过度症（HLP）的描述中未曾提及。电子显微镜图像显示膜被颗粒（MCG）和透明角质颗粒位于不同细胞中，这表明HLP中的角化异常可能是由于这些细胞之间的协作减少所致，且角化过程在没有MCG的情况下发生。口服维甲酸持续治疗取得了成功。
