Green P L, Xie Y M, Chen I S
Department of Medicine, University of California, Los Angeles, School of Medicine.
J Virol. 1991 Jan;65(1):546-50. doi: 10.1128/JVI.65.1.546-550.1991.
The Rex proteins of human T-cell leukemia virus types I and II (HTLV-I and HTLV-II) induce cytoplasmic expression of unspliced gag-pol mRNA and singly spliced env mRNA and are critical for virus replication. Two rex gene products, p27rex and p21rex of HTLV-I and p26rex and p24rex of HTLV-II, have been detected in HTLV-infected cells; however, the structural and biological relationship of the proteins has not been clearly elucidated. Endoproteinase digestion and phosphoamino acid analysis of HTLV-II Rex indicated that p24rex has the same amino acid backbone as p26rex and that the larger apparent molecular size of p26rex is attributable to serine phosphorylation.
人类T细胞白血病病毒I型和II型（HTLV-I和HTLV-II）的Rex蛋白可诱导未剪接的gag-pol mRNA和单剪接的env mRNA在细胞质中表达，对病毒复制至关重要。在HTLV感染的细胞中已检测到两种Rex基因产物，即HTLV-I的p27rex和p21rex以及HTLV-II的p26rex和p24rex；然而，这些蛋白质的结构和生物学关系尚未明确阐明。对HTLV-II Rex进行的内切蛋白酶消化和磷酸氨基酸分析表明，p24rex与p26rex具有相同的氨基酸主链，p26rex较大的表观分子大小归因于丝氨酸磷酸化。
