Rosenblatt J D, Cann A J, Slamon D J, Smalberg I S, Shah N P, Fujii J, Wachsman W, Chen I S
Department of Medicine, UCLA School of Medicine.
Science. 1988 May 13;240(4854):916-9. doi: 10.1126/science.2834826.
The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.
人类T细胞白血病病毒（HTLV）I型和II型有两个非结构基因，它们以重叠阅读框的形式编码。其中一个基因，称为tax，已被证明编码一种负责增强病毒长末端重复序列（LTRs）转录（反式激活）的蛋白质。遗传学证据表明，HTLV-II的第二个非结构基因，此处命名为rex，以浓度依赖的方式反式作用，调节tax基因介导的反式激活。rex基因可能在病毒生命周期中调节反式激活过程。
