Anderson K A
Parkview Internal Medicine Associates, St. Paul.
Postgrad Med. 1991 Jan;89(1):67-70, 75-6, 78. doi: 10.1080/00325481.1991.11700786.
Nitrate preparations are useful in the treatment of acute and chronic angina, acute and chronic congestive heart failure, and acute myocardial infarction. Development of tolerance is best managed by providing a nitrate-free interval, thus avoiding continuous drug levels. This interval probably should be 10 to 12 hours with use of a transdermal patch. Nitrate treatment of the elderly may require lower doses to avoid hypotension.
