Kale Ebru, Kuyumcuoğlu Umur, Kale Ahmet, Güzel Ali Irfan, Canoruc Naime
Department of Clinical Biochemistry, Dicle University School of Medicine, Diyarbakir, Turkey.
Fetal Diagn Ther. 2008;24(4):425-8. doi: 10.1159/000170093. Epub 2008 Nov 6.
To determine whether measurement of aspartate aminotransferase (Ast) and alanine aminotransferase (Alt) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (PPROM).
The PPROM group and normal pregnancy group consisted of 36 and 48 pregnant patients between 26 and 36 weeks' gestation, respectively. Vaginal fluid Ast and Alt levels were measured in both groups.
Vaginal fluid Alt level was not statistically significant in the PPROM group as compared with the control group (p = 0.064). Vaginal Ast level was statistically significant in the PPROM (14.4 +/- 17.46 U/l) group as compared with the control group (3.08 +/- 7.8 U/l; p = 0.001). The optimal cutoff value of 3 IU/l for Ast gave a sensitivity level of 91% at a specificity of 83%, with positive and negative predictive values of 80 and 93%, respectively.
Ast measurement from vaginal washing fluid appears to be a useful marker for the detection of PPROM.
确定检测阴道液中天冬氨酸转氨酶（Ast）和丙氨酸转氨酶（Alt）水平是否有助于诊断早产胎膜早破（PPROM）。
PPROM组和正常妊娠组分别由36例和48例妊娠26至36周的孕妇组成。检测两组孕妇的阴道液Ast和Alt水平。
与对照组相比，PPROM组的阴道液Alt水平无统计学意义（p = 0.064）。与对照组（3.08±7.8 U/l；p = 0.001）相比，PPROM组（14.4±17.46 U/l）的阴道Ast水平有统计学意义。Ast的最佳临界值为3 IU/l，灵敏度为91%，特异度为83%，阳性预测值和阴性预测值分别为80%和93%。
检测阴道冲洗液中的Ast似乎是检测PPROM的一个有用指标。
