Wan Ying, Xiao Bo, Dalai Siqin, Cao Xiaoying, Wu Quan
Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.
J Mater Sci Mater Med. 2009 Mar;20(3):719-24. doi: 10.1007/s10856-008-3622-z. Epub 2008 Nov 6.
Polycaprolactone (PCL) and chitosan were blended to fabricate porous scaffolds for tissue-engineering applications by employing a concentrated acetic acid solution as solvent and salt particles as porogen. These scaffolds showed well-controlled and interconnected porous structures. The pore size and porosity of the scaffolds could be effectively modulated by selecting appropriate amounts and sizes of porogen. The results obtained from compressive mechanical measurements indicated that PCL/chitosan could basically retain their strength in their dry state compared to individual components. In a hydrated state, their compressive stress and modulus could be still well maintained even though the weight ratio of chitosan reached around 50 wt%.
聚己内酯（PCL）和壳聚糖通过使用浓醋酸溶液作为溶剂、盐颗粒作为致孔剂进行共混，以制备用于组织工程应用的多孔支架。这些支架呈现出可控且相互连通的多孔结构。通过选择合适的致孔剂用量和尺寸，可以有效调节支架的孔径和孔隙率。压缩力学测量结果表明，与单个组分相比，PCL/壳聚糖在干燥状态下基本能保持其强度。在水合状态下，即使壳聚糖的重量比达到约50 wt%，其压缩应力和模量仍能得到很好的维持。
