Claas Frans H J
Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Int J Immunogenet. 2008 Aug;35(4-5):275-7. doi: 10.1111/j.1744-313x.2008.00800.x.
The introduction of very sensitive HLA antibody screening assays has destroyed the old dogma that pre-existence of donor specific HLA antibodies in the patient is a contra-indication for transplantation. The challenge is now to reach consensus on the parameters which predict the clinical relevance of donor specific HLA antibodies. Antibody screening assays should not only be used to prevent transplantation of patients with donor specific antibodies but also to facilitate transplantation of highly sensitized patients, both by defining acceptable HLA mismatches and non-detrimental donor specific HLA antibodies.
超灵敏HLA抗体筛查检测方法的引入打破了旧有观念，即患者体内预先存在供体特异性HLA抗体是移植的禁忌症。现在的挑战是就预测供体特异性HLA抗体临床相关性的参数达成共识。抗体筛查检测方法不仅应用于防止有供体特异性抗体的患者接受移植，还应通过确定可接受的HLA错配以及无害的供体特异性HLA抗体，来促进高度致敏患者的移植。
