Brzyski R G, Jones G S, Jones H W, Oehninger S, Muasher S J
Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
Fertil Steril. 1991 Jan;55(1):119-24. doi: 10.1016/s0015-0282(16)54070-9.
The impact of pituitary suppression with a gonadotropin-releasing hormone agonist (GnRH-a) on the luteal phase of in vitro fertilization (IVF) cycles was examined in 21 women who underwent identical stimulation regimens with and without leuprolide acetate pretreatment. The areas under the serum progesterone curves, measured over the 1st 10 days of the luteal phase, were significantly greater in the GnRH-a cycles compared with the non-GnRHa cycles, but when calculated per oocyte retrieved were similar in GnRH-a and non-GnRH-a cycles. In contrast, the areas under the luteal phase serum estradiol curves were significantly less in the GnRH-a cycles. These data suggest that GnRH-a treatment is accompanied by potentially beneficial alterations in the systemic steroidal milieu of the luteal phase of IVF cycles.
在21名接受相同刺激方案的女性中，研究了使用促性腺激素释放激素激动剂（GnRH-a）抑制垂体对体外受精（IVF）周期黄体期的影响，这些女性部分接受了醋酸亮丙瑞林预处理，部分未接受。在黄体期的前10天测量血清孕酮曲线下面积，GnRH-a周期显著大于非GnRH-a周期，但按回收的每个卵母细胞计算时，GnRH-a周期和非GnRH-a周期相似。相反，GnRH-a周期黄体期血清雌二醇曲线下面积显著更小。这些数据表明，GnRH-a治疗伴随着IVF周期黄体期全身甾体环境的潜在有益改变。
