Norman R J, Warnes G M, Segal S, McLoughlin J, Matthews C D
Reproductive Medicine Unit, Queen Elizabeth Hospital, Woodville, South Australia.
Fertil Steril. 1991 Jan;55(1):125-30. doi: 10.1016/s0015-0282(16)54071-0.
The concentrations of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured in the luteal phase of the cycle in patients undergoing ovarian hyperstimulation. In nonconception cycles, FSH and LH were increased in the late luteal phase compared with conception cycles in which both gonadotropins were suppressed. Estradiol (E2) and progesterone concentrations increased in pregnancy cycles and may be the sole cause for the decreased gonadotropin concentrations as shown by equivalent concentrations of LH and FSH in both pregnancy and nonpregnancy cycles after matching for E2 concentrations. Subjects who subsequently had twin pregnancy or a spontaneous abortion were compared with those with a successful ongoing singleton conception. There were no significant differences relative to LH and FSH between the three groups, although in twin pregnancy FSH tended to be lower at day 16 from oocyte recovery. It is concluded that suppression of LH and FSH in hyperstimulated pregnancy cycles occurs after the time of the rising human chorionic gonadotropin concentrations in plasma.
对接受卵巢过度刺激的患者在月经周期的黄体期测量促性腺激素、黄体生成素（LH）和卵泡刺激素（FSH）的浓度。在未受孕周期中，黄体晚期的FSH和LH相较于受孕周期升高，在受孕周期中两种促性腺激素均受到抑制。妊娠周期中雌二醇（E2）和孕酮浓度升高，匹配E2浓度后，妊娠周期和非妊娠周期中LH和FSH浓度相当，这可能是促性腺激素浓度降低的唯一原因。将随后发生双胎妊娠或自然流产的受试者与持续单胎妊娠成功的受试者进行比较。三组之间LH和FSH无显著差异，尽管在双胎妊娠中，从卵母细胞回收第16天起FSH往往较低。得出的结论是，在高刺激妊娠周期中，LH和FSH的抑制发生在血浆中人绒毛膜促性腺激素浓度上升之后。
