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在体外受精和胚胎移植中,自发性促黄体生成素(LH)激增与雌二醇(E2)和促卵泡激素(FSH)的更快升高有关。

Spontaneous luteinizing hormone (LH) surges are associated with more rapidly increasing estradiol (E2) and follicle stimulating hormone (FSH) in in vitro fertilization and embryo transfer.

作者信息

Kreiner D, Droesch K, Itskovitz J, Liu H C, Navot D, Rosenwaks Z

机构信息

Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk 23507.

出版信息

J In Vitro Fert Embryo Transf. 1988 Oct;5(5):265-7. doi: 10.1007/BF01132175.

DOI:10.1007/BF01132175
PMID:3148022
Abstract

In a retrospective analysis of 64 patients stimulated with human menopausal gonadotropin (hMG) and/or pure follicle stimulating hormone (FSH); 35 cycles with spontaneous luteinizing hormone (LH) surges were compared with 29 control cycles with respect to serum FSH and estradiol (E2) levels drawn on the day prior to and the day of human chorionic gonadotropin (hCG), approximately 16 hr after gonadotropin stimulation. FSH decreased significantly (P less than 0.05) in control cycles where two or more preovulatory oocytes (preovs) were obtained, in contrast to cycles with a spontaneous LH surge, where FSH increased irrespective of the number of preovs. The E2 increase in the LH surge cycles was significantly higher (P less than 0.05) than in the control cycles. However, the increase in E2 did not correlate with the change in FSH levels or with the number of preovs.

摘要

在一项对64例接受人绝经期促性腺激素(hMG)和/或纯促卵泡激素(FSH)刺激的患者的回顾性分析中,将35个出现自发性促黄体生成素(LH)峰的周期与29个对照周期在人绒毛膜促性腺激素(hCG)注射前一天及注射当天(促性腺激素刺激后约16小时)的血清促卵泡激素(FSH)和雌二醇(E2)水平进行了比较。在获得两个或更多排卵前卵母细胞(preovs)的对照周期中,FSH显著下降(P<0.05),而在出现自发性LH峰的周期中,无论preovs数量如何,FSH均升高。LH峰周期中E2的升高显著高于对照周期(P<0.05)。然而,E2的升高与FSH水平的变化或preovs数量均无相关性。

相似文献

1
Spontaneous luteinizing hormone (LH) surges are associated with more rapidly increasing estradiol (E2) and follicle stimulating hormone (FSH) in in vitro fertilization and embryo transfer.在体外受精和胚胎移植中,自发性促黄体生成素(LH)激增与雌二醇(E2)和促卵泡激素(FSH)的更快升高有关。
J In Vitro Fert Embryo Transf. 1988 Oct;5(5):265-7. doi: 10.1007/BF01132175.
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Hum Reprod. 1989 May;4(4):381-3. doi: 10.1093/oxfordjournals.humrep.a136911.
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The effect of human menopausal gonadotrophin and highly purified, urine-derived follicle stimulating hormone on the outcome of in-vitro fertilization in down-regulated normogonadotrophic women.人绝经期促性腺激素与高纯度尿源性促卵泡生成素对降调节的正常促性腺激素水平女性体外受精结局的影响
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The utility of a midcycle follicle-stimulating hormone boost in addition to human chorionic gonadotropin for timing of follicle aspiration in unstimulated in vitro fertilization cycles.在未刺激的体外受精周期中,除人绒毛膜促性腺激素外,在卵泡中期添加促卵泡生成素以确定卵泡抽吸时机的效用。
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本文引用的文献

1
Blockade of the estrogen-induced luteinizing hormone surge in monkeys: a nonsteroidal, antigenic factor in porcine follicular fluid.
Fertil Steril. 1984 Jan;41(1):108-13. doi: 10.1016/s0015-0282(16)47550-3.
2
Serum luteinizing hormone during ovulation induction with human menopausal gonadotropin for in vitro fertilization in normally menstruating women.
Fertil Steril. 1983 Dec;40(6):742-7. doi: 10.1016/s0015-0282(16)47473-x.
3
Follicle-stimulating hormone induced ovarian hyperstimulation in monkeys: blockade of the luteinizing hormone surge.促卵泡激素诱导猕猴卵巢过度刺激:黄体生成素峰的阻断
J Clin Endocrinol Metab. 1983 Jul;57(1):50-5. doi: 10.1210/jcem-57-1-50.
4
Growth curve analyses of follicular growth in the in vitro fertilization program.体外受精程序中卵泡生长的生长曲线分析。
Fertil Steril. 1986 Jun;45(6):834-8. doi: 10.1016/s0015-0282(16)49402-1.
5
In vitro fertilization management and results in stimulated cycles with spontaneous luteinizing hormone discharge.
Fertil Steril. 1986 Feb;45(2):231-6. doi: 10.1016/s0015-0282(16)49160-0.
6
Plasma inhibin levels during gonadotropin-induced ovarian hyperstimulation for IVF: a new index of follicular function?体外受精促性腺激素诱导卵巢过度刺激期间的血浆抑制素水平:卵泡功能的新指标?
Lancet. 1986 May 31;1(8492):1233-4. doi: 10.1016/s0140-6736(86)91385-1.